ArticleJournal of bacteriology2003
Identification and characterization of a Vibrio cholerae gene, mbaA, involved in maintenance of biofilm architecture.
Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
66 citing papers in PubMed.
- H-NOX and NosP Regulate Flagellar Protein and Virulence Factor Production in Vibrio Cholerae.Molecular & cellular proteomics : MCP · 2026Article
- Parallel regulatory circuits orchestrate biofilm formation in response to c-di-GMP levels and growth phase.PLoS genetics · 2025Article
- Review
- Cell-lysis sensing drives biofilm formation in Vibrio cholerae.Nature communications · 2024Article
- What makes another life possible in bacteria? Global regulators as architects of bacterial biofilms.World journal of microbiology & biotechnology · 2022Review
- Signal Transduction Network Principles Underlying Bacterial Collective Behaviors.Annual review of microbiology · 2022Review
- Exploring the dynamics of toxigenic environmental Vibrio mimicus and its comparative analysis with Vibrio cholerae of the southern Gangetic delta.Archives of microbiology · 2022Article
- Roles of the second messenger c-di-GMP in bacteria: Focusing on the topics of flagellar regulation and Vibrio spp.Genes to cells : devoted to molecular & cellular mechanisms · 2022Review
- Inverse regulation ofeLife · 2021Article
- A mutagenic screen reveals NspS residues important for regulation ofMicrobiology (Reading, England) · 2021Article
- A Heterogeneously Expressed Gene Family Modulates the Biofilm Architecture and Hypoxic Growth ofmBio · 2021Article
- Osmoregulated Periplasmic Glucans Transmit External Signals Through Rcs Phosphorelay Pathway inFrontiers in microbiology · 2020Article
- Silence is golden: gene silencing of V. cholerae during intestinal colonization delivers new aspects to the acid tolerance response.Gut microbes · 2019Article
- In vivo repressed genes ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Spermine inhibitsThe Journal of biological chemistry · 2017Article
- Relative contributions of norspermidine synthesis and signaling pathways to the regulation of Vibrio cholerae biofilm formation.PloS one · 2017Article
- The Bacterial Second Messenger Cyclic di-GMP Regulates Brucella Pathogenesis and Leads to Altered Host Immune Response.Infection and immunity · 2016Article
- Spermidine Inversely Influences Surface Interactions and Planktonic Growth in Agrobacterium tumefaciens.Journal of bacteriology · 2016Article
- Host intestinal signal-promoted biofilm dispersal induces Vibrio cholerae colonization.Infection and immunity · 2015Article
- Sub-MICs of Mentha piperita essential oil and menthol inhibits AHL mediated quorum sensing and biofilm of Gram-negative bacteria.Frontiers in microbiology · 2015Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The formation of biofilms is thought to play a key role in the environmental survival of the marine bacterium Vibrio cholerae. Although the factors involved in V. cholerae attachment to abiotic surfaces have been extensively studied, relatively little is known about the mechanisms involved in the subsequent maturation of the biofilms. Here we report the identification of a novel gene, which we have named mbaA (for maintenance of biofilm architecture), that plays a role in the formation and maintenance of the highly organized three-dimensional architecture of V. cholerae El Tor biofilms. We demonstrate that although the absence of mbaA does not significantly affect the initial attachment of cells onto the surface, it leads to the formation of biofilms that lack the typical structure, including the pillars of cells separated by fluid-filled channels that are evident in mature wild-type biofilms. Microscopic analysis indicates that the absence of mbaA leads to an increase in the amount of extracellular matrix material in the biofilms. The predicted mbaA product is a member of a family of regulatory proteins, containing GGDEF and EAL domains, suggesting that MbaA regulates the synthesis of some component of the biofilm matrix.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.