ArticleJournal of bacteriology2003
QscR, a LysR-type transcriptional regulator and CbbR homolog, is involved in regulation of the serine cycle genes in Methylobacterium extorquens AM1.
Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Widespread atypical response regulator SecR governs bacterial growth on methylamines through the serine cycle.Communications biology · 2026Article
- Aromatic acid metabolism inApplied and environmental microbiology · 2025Article
- Article
- CbbR, the Master Regulator for Microbial Carbon Dioxide Fixation.Journal of bacteriology · 2015Review
- Methenyl-Dephosphotetrahydromethanopterin Is a Regulatory Signal for Acclimation to Changes in Substrate Availability in Methylobacterium extorquens AM1.Journal of bacteriology · 2015Article
- Article
- Article
- Population heterogeneity in Methylobacterium extorquens AM1.Microbiology (Reading, England) · 2009Article
- Comprehensive proteomics of Methylobacterium extorquens AM1 metabolism under single carbon and nonmethylotrophic conditions.Proteomics · 2008Article
- Formate as the main branch point for methylotrophic metabolism in Methylobacterium extorquens AM1.Journal of bacteriology · 2008Article
- QscR acts as an intermediate in gacA-dependent regulation of PCA biosynthesis in Pseudomonas sp. M-18.Current microbiology · 2008Article
- QscR-mediated transcriptional activation of serine cycle genes in Methylobacterium extorquens AM1.Journal of bacteriology · 2005Article
- Flux analysis uncovers key role of functional redundancy in formaldehyde metabolism.PLoS biology · 2005Article
- Methylotrophy in Methylobacterium extorquens AM1 from a genomic point of view.Journal of bacteriology · 2003Review
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Authors and funding
2 authors.
Funding
Abstract
A new gene, qscR, encoding a LysR-type transcriptional regulator that is a homolog of CbbR, has been characterized from the facultative methylotroph Methylobacterium extorquens AM1 and shown to be the major regulator of the serine cycle, the specific C1 assimilation pathway. The qscR mutant was shown to be unable to grow on C1 compounds, and it lacked the activity of serine-glyoxylate aminotransferase, a key enzyme of the serine cycle. Activities of other serine cycle enzymes were decreased during growth on C1 compounds compared to the activities found in wild-type M. extorquens AM1. Promoter fusion assays, as well as reverse transcription-PCR assays, have indicated that the serine cycle genes belong to three separate transcriptional units, sga-hpr-mtdA-fch, mtkA-mtkB-ppc-mcl, and gly. Gel retardation assays involving the purified QscR have demonstrated the specific binding of QscR to the DNA regions upstream of sga, mtkA, gly, and qscR. We conclude that QscR acts as a positive transcriptional regulator of most of the serine cycle enzymes and also as an autorepressor.
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