ReviewCurrent allergy and asthma reports2003
Airway vascular remodeling in asthma.
Review in Current allergy and asthma reports, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- New methods for monitoring dynamic airway tissue oxygenation and perfusion in experimental and clinical transplantation.American journal of physiology. Lung cellular and molecular physiology · 2012Trial
- Mechanical force-induced tissue remodelling in a clinically relevant microphysiological model of asthmatic human lungs.Nature biomedical engineering · 2026Article
- Analyzing soluble and lung smooth muscle laminin isoform expression in guinea pigs exhibiting various allergic response phenotypes.Frontiers in immunology · 2026Article
- LYVE-1 identifies asthma and drives PDGF-BB-induced proliferation, migration, and oxidative stress in airway smooth muscle cells via the PI3K/Akt pathway.Frontiers in pharmacology · 2026Article
- Diabetic endothelial microangiopathy and pulmonary dysfunction.Frontiers in endocrinology · 2023Review
- Bronchial Vascular Remodeling Is Attenuated by Anti-IL-17 in Asthmatic Responses Exacerbated by LPS.Frontiers in pharmacology · 2020Article
- The role of bone marrow-derived endothelial progenitor cells and angiogenic responses in chronic obstructive pulmonary disease.Journal of thoracic disease · 2017Review
- Angiopoietin-2 concentration in serum is associated with severe asthma phenotype.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2016Article
- The Three A's in Asthma - Airway Smooth Muscle, Airway Remodeling & Angiogenesis.The open respiratory medicine journal · 2015Article
- Proteolytic Activity Present in House-Dust-Mite Extracts Degrades ENA-78/CXCL5 and Reduces Neutrophil Migration.Journal of allergy · 2014Article
- Article
- Perceptual accuracy of upper airway compromise in children: Clinical relevance and future directions for research.Allergy & rhinology (Providence, R.I.) · 2013Article
- Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation.The American journal of pathology · 2012Article
- Role of Inhaled Steroids in Vascular Airway Remodelling in Asthma and COPD.International journal of endocrinology · 2012Article
- Ion channels in asthma.The Journal of biological chemistry · 2011Review
- The role of the bronchial microvasculature in the airway remodelling in asthma and COPD.Respiratory research · 2010Review
- The impact of asthma on the gastrointestinal tract (GIT).Journal of asthma and allergy · 2010Article
- Steroid-resistant lymphatic remodeling in chronically inflamed mouse airways.The American journal of pathology · 2010Article
- Tissue-engineered endothelial and epithelial implants differentially and synergistically regulate airway repair.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Pulmonary allergic reactions impair systemic vascular relaxation in ragweed sensitive mice.Vascular pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several characteristic changes occur in the bronchial wall in asthma, including specific changes to the vasculature. These result in an increase in vessel numbers per unit area, as well as increased vessel activity suggested by vasodilatation, vessel leakage, and cellular margination with transmigration to target tissues. This combined action in asthma leads to airway-wall thickening and reduced airflow. Each component of the vascular response has been shown to be controlled by a range of inflammatory mediators and growth factors. These factors are themselves regulated by a complex process initially involving gene expression, transcription, and translation at the molecular level, then subsequent protein release, binding to matrix elements, endothelial cell activation, and a proliferative endothelial response. Many commonly used airway medications are capable of modulating the vascular response to inflammatory stimuli. New therapies might improve airflow through better regulation of vessel growth, dilatation, and leakage in the airway wall.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.