ArticleClinical and experimental immunology2003
Enhanced chemokine response in experimental acute Escherichia coli pyelonephritis in IL-1beta-deficient mice.
Article in Clinical and experimental immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- PTEN modulates urinary tract infection susceptibility and shapes urothelial antibacterial defenses.Life science alliance · 2025Article
- Estrogen-stimulated uropathogenic E. coli mediate enhanced neutrophil responses.Scientific reports · 2024Article
- Trimethylamine N-Oxide (TMAO) Mediates Increased Inflammation and Colonization of Bladder Epithelial Cells during a UropathogenicPathogens (Basel, Switzerland) · 2023Article
- The role of caspase-1, caspase-4 and NLRP3 in regulating the host cell response evoked by uropathogenic Escherichia coli.Scientific reports · 2022Article
- Article
- Human Renal Fibroblasts, but Not Renal Epithelial Cells, Induce IL-1β Release during a UropathogenicCells · 2021Article
- Activation of NLRP3 by uropathogenic Escherichia coli is associated with IL-1β release and regulation of antimicrobial properties in human neutrophils.Scientific reports · 2020Article
- Impact of Proinflammatory Cytokines on the Virulence of UropathogenicFrontiers in microbiology · 2019Article
- Activation of the NLRP3 Inflammasome Pathway by UropathogenicFrontiers in cellular and infection microbiology · 2018Article
- Immunity to uropathogens: the emerging roles of inflammasomes.Nature reviews. Urology · 2017Review
- Article
- Urine heat shock protein 70 levels as a marker of urinary tract infection in children.Pediatric nephrology (Berlin, Germany) · 2016Article
- Multi-step pathogenesis and induction of local immune response by systemic Candida albicans infection in an intravenous challenge mouse model.International journal of molecular sciences · 2014Article
- Is the inflammasome a potential therapeutic target in renal disease?BMC nephrology · 2014Article
- Glibenclamide reduces pro-inflammatory cytokine production by neutrophils of diabetes patients in response to bacterial infection.Scientific reports · 2013Article
- The IL-6 -174G/C polymorphism and renal scarring in children with first acute pyelonephritis.Pediatric nephrology (Berlin, Germany) · 2010Article
- Urine macrophage migration inhibitory factor (MIF) in children with urinary tract infection: a possible predictor of acute pyelonephritis.Pediatric nephrology (Berlin, Germany) · 2009Article
- Mechanisms of disease: regulation of RANTES (CCL5) in renal disease.Nature clinical practice. Nephrology · 2007Review
- Tumor necrosis factor alpha- and inducible nitric oxide synthase-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection but are dispensable for bacterial clearance.Infection and immunity · 2006Article
- Strikingly higher interleukin (IL)-1alpha, IL-1beta and soluble interleukin-1 receptor antagonist (sIL-1RA) but similar IL-2, sIL-2R, IL-3, IL-4, IL-6, sIL-6R, IL-10, tumour necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta and interferon IFN-gamma urine levels in healthy females compared to healthy males: protection against urinary tract injury?Clinical and experimental immunology · 2005Article
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to investigate the effects of IL-1beta and Escherichia coli on the expression and secretion of MIP-2, the mouse equivalent to human IL-8, MCP-1 and RANTES in the kidneys of mice with acute pyelonephritis. Female Bki NMRI, as well as IL-1beta deficient mice and their wild-type littermates, were transurethrally infected with either E. coli CFT 073 or injected with NaCl 0.9% (w/v) and thereafter obstructed for 6 h. The Bki NMRI mice were killed at 0, 24, 48 h and 6 days and the IL-1beta-deficient mice at 48 h. Chemokine mRNA and protein levels peaked at 24 h for the tested chemokines with the mRNA expression localized in the tubular epithelial cells and for MIP-2 also in neutrophils. Obstruction per se, also induced a chemokine expression similar to E. coli infection although at a lower level. Interestingly, MIP-2 levels were higher in the IL-1beta deficient mice as compared with the wild-type littermates. Likewise, the inflammatory changes were more frequent and, when present, more widespread in the IL-1beta-deficient mice than in the wild-type mice. Stimulation of a human renal tubular epithelial cell line (HREC), A498 and of primary human mesangial cells (HMC) with the same bacterial antigen depicted gene expression of the same chemokines. A rapid release of IL-8 and MCP-1 was observed from both cell types. RANTES response was delayed both in the HREC and the HMC. We conclude that acute E. coli pyelonephritis induces a MIP-2/IL-8, MCP-1 and RANTES expression and secretion localized primarily to the epithelial cells and that this production is confirmed after in vitro stimulation with the same bacterial antigen of human epithelial and mesangial cells. Blockade of induction of chemokine response may thus be an attractive target for possible therapeutic intervention.
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