Evidence map›Paper›PMID 12560779›Full record

Trial reportAnnals of surgery2003

Portal vein embolization before right hepatectomy: prospective clinical trial.

Olivier Farges, Jacques Belghiti, Reza Kianmanesh, Jean Marc Regimbeau, Roberto Santoro, Valérie Vilgrain, Alban Denys, Alain Sauvanet

Registry-linked trialOpen access · greenAbstract readClinical TrialComparative StudyControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of surgery, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02184182 (Liver Resection After Portal Vein Ligation / Embolization and Transection Plane Devascularization With Radio Frequency / Microwave), which is not on this map. Cited by 237 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
237citing papers in PubMed, 15 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02184182 phase2unknown statusnot on this mapstarted 2014, after this paper: background citation

Liver Resection After Portal Vein Ligation / Embolization and Transection Plane Devascularization With Radio Frequency / Microwave: Pilot Study on Primary and Secondary Liver Tumors

TypeinterventionalSponsorAzienda Ospedaliera di PadovaRan2014 to 2017Enrolled10ConditionsLiver TumorsArmsVLS ablation/portal ligation/hepatectomy
3 · Its place in the literature

Who cites it

237 citing papers in PubMed, 15 syntheses or guidelines pooled it, 665 citations in OpenAlex.

  1. Pooled it
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  7. Guideline
  8. Pooled it
  9. Systematic review of pathophysiological changes following hepatic resection.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2014
    Pooled it
  10. A systematic review of two-stage hepatectomy in patients with initially unresectable colorectal liver metastases.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2013
    Pooled it
  11. Portal vein embolization before liver resection: a systematic review.Cardiovascular and interventional radiology · 2013
    Pooled it
  12. Selection for hepatic resection of colorectal liver metastases: expert consensus statement.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2013
    Guideline
  13. Dramatic innovations in modern surgical subspecialties.Canadian journal of surgery. Journal canadien de chirurgie · 2010
    Pooled it
  14. Pretreatment assessment of hepatocellular carcinoma: expert consensus statement.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2010
    Guideline
  15. NCCN clinical practice guidelines in oncology: hepatobiliary cancers.Journal of the National Comprehensive Cancer Network : JNCCN · 2009
    Guideline
  16. Trial
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  19. Improved long-term survival after major resection for hepatocellular carcinoma: a multicenter analysis based on a new definition of major hepatectomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2013
    Trial
  20. Trial

177 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Olivier FargesDepartment of Digestive Surgery, Hospital Beaujon, 100, Boulevard du Général Leclerc, 92118 Clichy Cedex, France.
Jacques Belghiti
Reza Kianmanesh
Jean Marc Regimbeau
Roberto Santoro
Valérie Vilgrain
Alban Denys
Alain Sauvanet
Hôpital Beaujon · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the impact of liver hypertrophy of the future liver remnant volume (FLR) induced by preoperative portal vein embolization (PVE) on the immediate postoperative complications after a standardized major liver resection. SUMMARY BACKGROUND DATA: PVE is usually indicated when FLR is estimated to be too small for major liver resection. However, few data exist regarding the exact quantification of sufficient minimal functional hepatic volume required to avoid postoperative complications in both patients with or without chronic liver disease.

methodsAll consecutive patients in whom an elective right hepatectomy was feasible and who fulfilled the inclusion and exclusion criteria between 1998 and 2000 were assigned to have alternatively either immediate surgery or surgery after PVE. Among 55 patients (25 liver metastases, 2 cholangiocarcinoma, and 28 hepatocellular carcinoma), 28 underwent right hepatectomy after PVE and 27 underwent immediate surgery. Twenty-eight patients had chronic liver disease. FLR and estimated rate of functional future liver remnant (%FFLR) volumes were assessed by computed tomography.

resultsThe mean increase of FLR and %FFLR 4 to 8 weeks after PVE were respectively 44 +/- 19% and 16 +/- 7% for patients with normal liver and 35 +/- 28% and 9 +/- 3% for those with chronic liver disease. All patients with normal liver and 86% with chronic liver disease experienced hypertrophy after PVE. The postoperative course of patients with normal liver who underwent PVE before right hepatectomy was similar to those with immediate surgery. In contrast, PVE in patients with chronic liver disease significantly decreased the incidence of postoperative complications as well as the intensive care unit stay and total hospital stay after right hepatectomy.

conclusionsBefore elective right hepatectomy, the hypertrophy of FLR induced by PVE had no beneficial effect on the postoperative course in patients with normal liver. In contrast, in patients with chronic liver disease, the hypertrophy of the FLR induced by PVE decreased significantly the rate of postoperative complications.

Indexed as

Embolization, TherapeuticPortal VeinAdultAgedBody Weights and MeasuresChronic DiseaseFemaleHepatectomyHumansHypertrophyLiverLiver DiseasesLiver Function TestsMaleMiddle AgedPostoperative Complications

Identifiers

PMID12560779
PMCPMC1522143
OpenAlexW1971409448

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.