ArticleNucleic acids research2003
Genome instability in rad54 mutants of Saccharomyces cerevisiae.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Iron, manganese, and copper complexes protect saccharomyces cerevisiae from methyl methanesulfonate-induced genotoxicity and oxidative stress.World journal of microbiology & biotechnology · 2025Article
- The translocation activity of Rad54 reduces crossover outcomes during homologous recombination.Nucleic acids research · 2024Article
- Rdh54 stabilizes Rad51 at displacement loop intermediates to regulate genetic exchange between chromosomes.PLoS genetics · 2022Article
- Analysis of the activities of RAD54, a SWI2/SNF2 protein, using a specific small-molecule inhibitor.The Journal of biological chemistry · 2013Article
- Bridge-induced chromosome translocation in yeast relies upon a Rad54/Rdh54-dependent, Pol32-independent pathway.PloS one · 2013Article
- Opposite modifying effects of HR and NHEJ deficiency on cancer risk in Ptc1 heterozygous mouse cerebellum.Oncogene · 2011Article
- Functions of the Snf2/Swi2 family Rad54 motor protein in homologous recombination.Biochimica et biophysica acta · 2011Review
- Swi2/Snf2-related translocases prevent accumulation of toxic Rad51 complexes during mitotic growth.Molecular cell · 2010Article
- Rad54, the motor of homologous recombination.DNA repair · 2010Review
- Synergistic action of the Saccharomyces cerevisiae homologous recombination factors Rad54 and Rad51 in chromatin remodeling.DNA repair · 2007Article
- Rad51 and Rad54 ATPase activities are both required to modulate Rad51-dsDNA filament dynamics.Nucleic acids research · 2007Article
- Selection and analysis of spontaneous reciprocal mitotic cross-overs in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis.Molecular and cellular biology · 2006Article
- Rad54: the Swiss Army knife of homologous recombination?Nucleic acids research · 2006Review
- Expression of a human cytochrome p450 in yeast permits analysis of pathways for response to and repair of aflatoxin-induced DNA damage.Molecular and cellular biology · 2005Article
- Opposing roles for DNA structure-specific proteins Rad1, Msh2, Msh3, and Sgs1 in yeast gene targeting.The EMBO journal · 2005Article
- Schizosaccharomyces pombe Rdh54 (TID1) acts with Rhp54 (RAD54) to repair meiotic double-strand breaks.Molecular biology of the cell · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The RAD54 gene of Saccharomyces cerevisiae encodes a conserved dsDNA-dependent ATPase of the Swi2/Snf2 family with a specialized function during recombinational DNA repair. Here we analyzed the consequences of the loss of Rad54 function in vegetative (mitotic) cells. Mutants in RAD54 exhibited drastically reduced rates of spontaneous intragenic recombination but were proficient for spontaneous intergenic recombinant formation. The intergenic recombinants likely arose by a RAD54-independent pathway of break-induced replication. Significantly increased rates of spontaneous chromosome loss for diploid rad54/rad54 cells were identified in several independent assays. Inter estingly, the increase in chromosome loss appeared to depend on the presence of a homolog. In addition, the rate of complex genetic events involving chromosome loss were drastically increased in diploid rad54/rad54 cells. Together, these data suggest a role for Rad54 protein in the repair of spontaneous damage, where in the absence of Rad54 protein, homologous recombination is initiated but not properly terminated, leading to misrepair and chromosome loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.