Evidence map›Paper›PMID 12558469›Full record

SynthesisPharmacoEconomics2003

A meta-analysis of quality-of-life estimates for stroke.

Tammy O Tengs, Ting H Lin

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in PharmacoEconomics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  6. A meta-analysis of health state valuations for people with diabetes: explaining the variation across methods and implications for economic evaluation.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2011
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  20. A Meta-Regression Analysis of Utility Weights for Breast Cancer: The Power of Patients' Experience.International journal of environmental research and public health · 2020
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tammy O TengsHealth Priorities Research Group, School of Social Ecology, University of California, Irvine, California 92697-7076, USA. tengs@uci.edu
Ting H Lin

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResearchers performing cost-effectiveness analyses often incorporate quality-of-life (QOL) estimates.

objectiveTo aid analysts, we performed a meta-analysis to estimate quality of life for minor, moderate, and major stroke and assessed the relative importance of study design characteristics in predicting the quality of life of patients with stroke.

methodsThrough a systematic search we identified 20 articles reporting 53 unique QOL weights for stroke. Each article was read and QOL weights and study characteristics were recorded. We used a hierarchical linear model (HLM) to perform a meta-regression. The model included severity of stroke, elicitation method, respondents, and QOL scale bounds as explanatory variables.

resultsSeverity of stroke (p < 0.0001) and the bounds of the scale (p = 0.0015) were significant predictors of quality of life, while the elicitation method and respondents were not. Pooling QOL weights using the HLM model, we estimated a quality of life of 0.52 for major stroke, 0.68 for moderate stroke, and 0.87 for minor stroke if the time trade-off method is used to assess quality of life from community members when the scale bounds range from death to perfect health.

conclusionsWe found no systematic difference in stroke QOL weights depending on elicitation method or respondents. However, quality of life is sensitive to the bounds of the scale. Because the pooled QOL estimates reported here are based on a comprehensive review of the QOL literature for stroke, they should be of great use to researchers performing cost-utility analyses of interventions designed to prevent or treat stroke, or where stroke is a possible side effect of therapy.

Indexed as

Quality of LifeHealth StatusHumansSeverity of Illness IndexStroke

Identifiers

PMID12558469

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.