ReviewLipids2002
Clinical trial results support a preference for using CLA preparations enriched with two isomers rather than four isomers in human studies.
Review in Lipids, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- The effect of conjugated linoleic acid supplementation in comparison with omega-6 and omega-9 on lipid profile: a graded, dose-response systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2024Pooled it
- Trial
- Atheroprotective effects of conjugated linoleic acid.British journal of clinical pharmacology · 2017Review
- Pros and cons of CLA consumption: an insight from clinical evidences.Nutrition & metabolism · 2015Review
- Moderate doses of conjugated linoleic acid reduce fat gain, maintain insulin sensitivity without impairing inflammatory adipose tissue status in mice fed a high-fat diet.Nutrition & metabolism · 2010Article
- Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver.Physiological genomics · 2009Article
- Conjugated linoleic acid modulation of risk factors associated with atherosclerosis.Nutrition & metabolism · 2008Article
- Physico-chemical modifications of conjugated linoleic acid for ruminal protection and oxidative stability.Nutrition & metabolism · 2008Article
- Isomer specificity of conjugated linoleic acid (CLA): 9E,11E-CLA.Nutrition research and practice · 2008Article
- The body fat-lowering effect of conjugated linoleic acid: a comparison between animal and human studies.Journal of physiology and biochemistry · 2006Review
- Lymphatic transport in rats of interesterified oils containing conjugated linoleic acids.Lipids · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CLA mixtures are now commercially available. They differ from each other with respect to their content of CLA isomers and their degree of purification. As a group of natural FA, CLA have been widely assumed to be safe. However, the suspected presence of both impurities and particular isomers might induce undesirable side effects. Despite this potential health risk, only a few CLA preparations have been tested under rigorous conditions for clinical efficacy and safety. Based on the limited results available, it is possible to suggest that preparations enriched in c9,t11 and t10,c12 isomers are preferable for human consumption compared to preparations containing four isomers, in terms both of safety and efficacy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.