ArticleImmunogenetics2003
Functional analysis of a promoter variant of the gene encoding the interferon-gamma receptor chain I.
Article in Immunogenetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 66 citations in OpenAlex.
- Deregulation of interferon-gamma receptor 1 expression and its implications for lung adenocarcinoma progression.World journal of clinical oncology · 2024Review
- Investigation of the relationship between interferon-gamma receptor 1-56C/T gene polymorphism and genetic susceptibility to lung sarcoidosis: A cross-sectional study.Archives of rheumatology · 2023Article
- Interferon gamma gene polymorphisms and chronic hepatitis B infections in an Iranian population.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Article
- Genetic Polymorphisms ofDisease markers · 2019Article
- Investigation of single and synergic effects of NLRC5 and PD-L1 variants on the risk of colorectal cancer.PloS one · 2018Article
- Association of Interferon-The American journal of tropical medicine and hygiene · 2017Article
- Distribution of PTPN22 polymorphisms in SLE from western Mexico: correlation with mRNA expression and disease activity.Clinical and experimental medicine · 2016Article
- Association between IFN-γ +874A/T and IFN-γR1 (-611A/G, +189T/G, and +95C/T) Gene Polymorphisms and Chronic Periodontitis in a Sample of Iranian Population.International journal of dentistry · 2015Article
- Article
- Association of PTPN22 gene (rs2488457) polymorphism with ulcerative colitis and high levels of PTPN22 mRNA in ulcerative colitis.International journal of colorectal disease · 2013Article
- In-vitro characterization of novel and functional regulatory SNPs in the promoter region of IL2 and IL2R alpha in a Gabonese population.BMC medical genetics · 2012Article
- A PTPN22 promoter polymorphism -1123G>C is associated with RA pathogenesis in Chinese.Rheumatology international · 2012Article
- Combined promoter haplotypes of the IL10R genes are associated with protection against severe malaria in Gabonese children.Immunogenetics · 2012Article
- Novel and functional regulatory SNPs in the promoter region of FOXP3 gene in a Gabonese population.Immunogenetics · 2011Article
- Interplay of host and infectious agents.Wiener klinische Wochenschrift · 2010Article
- A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection.Immunogenetics · 2009Article
- Immunity to malaria: more questions than answers.Nature immunology · 2008Review
- IFNG and IFNGR1 gene polymorphisms and susceptibility to post-kala-azar dermal leishmaniasis in Sudan.Genes and immunity · 2007Article
- Associations of the IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFN (gamma) R1 cytokine receptor genes with AIDS progression in a French AIDS cohort.Immunogenetics · 2006Article
- How malaria has affected the human genome and what human genetics can teach us about malaria.American journal of human genetics · 2005Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyzed a single nucleotide polymorphism (SNP) at position -56 (T-->C) in the promoter region of the gene encoding the human interferon-gamma receptor ligand-binding chain I (IFN-gammaR1). The mutation was present at similar frequencies in Gabonese children with either mild or severe malaria. Functional investigations of the promoter in a transfected human B-cell line showed lower levels of luciferase reporter gene expression in the presence of the mutation, indicating the importance of this position for promoter activity, and suggesting that this SNP might negatively influence the expression level of IFN-gammaR1 at the cell surface. Further examinations of the DNA sequence at this polymorphic site showed a perfectly matched binding site for the transcription factor activator protein 4 (AP-4) on both strands. Binding sites for other important transcription factors involved in gene expression and regulation of the immune response against infections, including Ikaros 2 (Ik-2), nuclear factor kappaB (NFkappaB), and CETS1p54, are also situated in this region.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.