ArticleBritish journal of cancer2003
Staurosporine-induced apoptosis and hydrogen peroxide-induced necrosis in two human breast cell lines.
Article in British journal of cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 86 citations in OpenAlex.
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- Strong and sustained activation of the anticipatory unfolded protein response induces necrotic cell death.Cell death and differentiation · 2018Article
- An effective "three-in-one" screening assay for testing drug and nanoparticle toxicity in human endothelial cells.PloS one · 2018Article
- JNK Activation Contributes to Oxidative Stress-Induced Parthanatos in Glioma Cells via Increase of Intracellular ROS Production.Molecular neurobiology · 2017Article
- Markers and Biomarkers of Endothelium: When Something Is Rotten in the State.Oxidative medicine and cellular longevity · 2017Review
- Novel CHOP activator LGH00168 induces necroptosis in A549 human lung cancer cells via ROS-mediated ER stress and NF-κB inhibition.Acta pharmacologica Sinica · 2016Article
- Evidence of a Role for Fibroblast Transient Receptor Potential Canonical 3 Ca2+ Channel in Renal Fibrosis.Journal of the American Society of Nephrology : JASN · 2015Article
- n-Butanol extract of Rhynchosia volubilis Lour: a potent spermicidal agent In Vitro.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2014Article
- Amphipathic polymer-mediated uptake of trehalose for dimethyl sulfoxide-free human cell cryopreservation.Cryobiology · 2013Article
- Roles of BN52021 in platelet-activating factor pathway in inflammatory MS1 cells.World journal of gastroenterology · 2013Article
- Hornerin, an S100 family protein, is functional in breast cells and aberrantly expressed in breast cancer.BMC cancer · 2012Article
- A multi-scale modeling framework for individualized, spatiotemporal prediction of drug effects and toxicological risk.Frontiers in pharmacology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of apoptosis-inducing agents in the treatment of malignant cancer is increasingly being considered as a therapeutic approach. In this study, the induction of apoptosis and necrosis was examined in terms of temporal dose responses, comparing a malignant and nonmalignant breast cell line. Staurosporine (SSP)-induced apoptosis and H(2)O(2)-induced necrosis were evaluated by two cytotoxicity assays, neutral red (NR) and methyl-thiazolyl tertrazolium (MTT), in comparison with a differential dye uptake assay, using Hoechst33342/propidium iodide (Hoechst/PI). Confirmatory morphological assessment was also performed by routine resin histology and transmission electron microscopy. Cell viability was assessed over a 0.5-48 h time course. In nonmalignant HBL-100 cells, 50 nM SSP induced 100% apoptosis after a 48 h exposure, while the same exposure to SSP caused only 4% apoptosis in metastatic T47D cells. Although complete apoptosis of both cell lines was induced by 50 microM SSP, this effect was delayed in T47D (24 h) compared with HBL-100 (4 h). Results also showed that neither MTT or NR can distinguish between the modes of cell death, nor detect the early onset of apoptosis revealed by Hoechst/PI.
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