ArticleBritish journal of cancer2003
Mitochondrial DNA damage in non-melanoma skin cancer.
Article in British journal of cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 94 citations in OpenAlex.
- The mutational analysis of mitochondrial DNA in maternal inheritance of polycystic ovarian syndrome.Frontiers in endocrinology · 2023Article
- The mitochondrial RNA polymerase POLRMT promotes skin squamous cell carcinoma cell growth.Cell death discovery · 2022Article
- Human Mitochondrial DNA Polymerase Metal Dependent UV Lesion Bypassing Ability.Frontiers in molecular biosciences · 2022Article
- Current Progress and Perspectives on Using Gold Compounds for the Modulation of Tumor Cell Metabolism.Frontiers in chemistry · 2021Review
- Mitochondrial DNA as a Sensitive Biomarker of UV-Induced Cellular Damage in Human Skin.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing.PLoS genetics · 2020Article
- Mitochondria in skin health, aging, and disease.Cell death & disease · 2020Review
- PARP1 Inhibition Augments UVB-Mediated Mitochondrial Changes-Implications for UV-Induced DNA Repair and Photocarcinogenesis.Cancers · 2019Article
- Heteroplasmy and Copy Number Variations of Mitochondria in 88 Hepatocellular Carcinoma Individuals.Journal of Cancer · 2017Article
- Mitochondrial DNA 4977-base pair common deletion in blood leukocytes and melanoma risk.Pigment cell & melanoma research · 2016Article
- Key Roles of Glutamine Pathways in Reprogramming the Cancer Metabolism.Oxidative medicine and cellular longevity · 2015Review
- Mitochondria and cancer: past, present, and future.BioMed research international · 2013Review
- Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction.DNA repair · 2012Article
- Human mitochondrial DNA polymerase γ exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers.The Journal of biological chemistry · 2012Article
- Mitochondrial haplogroups and polymorphisms reveal no association with sporadic prostate cancer in a southern European population.PloS one · 2012Article
- Article
- Analysis of mitochondrial ND1 gene in human colorectal cancer.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2011Article
- Molecular markers in cutaneous squamous cell carcinoma.International journal of surgical oncology · 2011Article
- Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging.The Journal of experimental medicine · 2010Article
- Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis.Cell research · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial DNA (mtDNA) damage, predominantly encompassing point mutations, has been reported in a variety of cancers. Here we present in human skin, the first detailed study of the distribution of multiple forms of mtDNA damage in nonmelanoma skin cancer (NMSC) compared to histologically normal perilesional dermis and epidermis. We present the first entire spectrum of deletions found between different types of skin tumours and perilesional skin. In addition, we provide the first quantitative data for the incidence of the common deletion as well as the first report of specific tandem duplications in tumours from any tissue. Importantly, this work shows that there are clear differences in the distribution of deletions between the tumour and the histologically normal perilesional skin. Furthermore, DNA sequencing of four mutation 'hotspot' regions of the mitochondrial genome identified a previously unreported somatic heteroplasmic mutation in an SCC patient. In addition, 81 unreported and reported homoplasmic single base changes were identified in the other NMSC patients. Unlike the distribution of deletions and the heteroplasmic mutation, these homoplasmic mutations were present in both tumour and perilesional skin, which suggests that for some genetic studies the traditional use of histologically normal perilesional skin from NMSC patients may be limited. Currently, it is unclear whether mtDNA damage has a direct link to skin cancer or it may simply reflect an underlying nuclear DNA instability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.