Evidence map›Paper›PMID 12556961›Full record

SynthesisBritish journal of cancer2003

Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis.

G M Clifford, J S Smith, M Plummer, N Muñoz, S Franceschi

Registry-linked trialOpen access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in British journal of cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03324009 (Development of a Two-stage Cervical Cancer Screening Algorithm for Botswana), which is not on this map. Cited by 494 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
494citing papers in PubMed, 6 pooled it
43.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03324009 nacompletednot on this mapstarted 2018, after this paper: background citation

Development of a Two-stage Cervical Cancer Screening Algorithm for Botswana

TypeinterventionalSponsorBeth Israel Deaconess Medical CenterRan2018 to 2020Enrolled239ConditionsCervical Cancer, HIV/AIDSArms2-stage screen
3 · Its place in the literature

Who cites it

494 citing papers in PubMed, 6 syntheses or guidelines pooled it, 1,561 citations in OpenAlex.

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434 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

G M CliffordInternational Agency for Research on Cancer, 150, cours Albert Thomas, 69008 Lyon, France. clifford@iarc.fr
J S Smith
M Plummer
N Muñoz
S Franceschi
Centre International de Recherche sur le Cancer · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated regional variations in the contribution made by different human papilloma (HPV) types to invasive cervical cancer (ICC). A total of 85 studies using polymerase chain reaction to estimate HPV prevalence in ICC were identified. Data on HPV prevalence were extracted separately for squamous cell carcinoma (SCC) and for adeno- and adenosquamous-carcinoma (ADC). A total of 10 058 cases (8550 SCC, 1508 ADC) were included in pooled analyses. The most common HPV types in ICC were, in order of decreasing prevalence, HPV16, 18, 45, 31, 33, 58, 52, 35, 59, 56, 6, 51, 68, 39, 82, 73, 66 and 70. In SCC, HPV16 was the predominant type (46-63%) followed by HPV18 (10-14%), 45 (2-8%), 31 (2-7%) and 33 (3-5%) in all regions except Asia, where HPV types 58 (6%) and 52 (4%) were more frequently identified. In ADC, HPV prevalence was significantly lower (76.4%) than in SCC (87.3%), and HPV18 was the predominant type in every region (37-41%), followed by 16 (26-36%) and 45 (5-7%). The overall detection of HPV DNA was similar in different regions (83-89%). A majority of ICC was associated with HPV16 or 18 in all regions, but approximately a quarter of all ICC cases were associated with one of 16 other HPV types, their distribution varying by region.

Indexed as

FemaleHumansNeoplasm InvasivenessPapillomaviridaePapillomavirus InfectionsPrevalenceTumor Virus InfectionsUterine Cervical Neoplasms

Identifiers

PMID12556961
PMCPMC2376782
OpenAlexW2012868689

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.