ArticleMolecular psychiatry2003
Association between a dinucleotide repeat polymorphism of the estrogen receptor alpha gene and personality traits in women.
Article in Molecular psychiatry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 57 citations in OpenAlex.
- Variations in estrogen receptor alpha gene and risk of dementia, and brain volumes on MRI.Molecular psychiatry · 2004Trial
- Association Study of Hyaluronan-Binding Protein 2 (International journal of molecular sciences · 2025Article
- Interplay of polymorphisms in sex hormone receptors and facial sexual differentiation in shaping prosocial behavior.Scientific reports · 2025Article
- The association of 20 short tandem repeat loci of autosomal chromosome with male schizophrenia.Brain and behavior · 2022Article
- The influence of microsatellite polymorphisms in sex steroid receptor genes ESR1, ESR2 and AR on sex differences in brain structure.NeuroImage · 2020Article
- Neuroendocrine stress response is moderated by sex and sex hormone receptor polymorphisms.Hormones and behavior · 2018Article
- Hyaluronan-binding protein 2 (HABP2) gene variation in women with recurrent miscarriage.BMC women's health · 2018Article
- Linking Y-chromosomal short tandem repeat loci to human male impulsive aggression.Brain and behavior · 2017Article
- Polymorphisms in sex steroid receptors: From gene sequence to behavior.Frontiers in neuroendocrinology · 2017Review
- Genetic determinants of aggression and impulsivity in humans.Journal of applied genetics · 2012Review
- Is the Gly82Ser polymorphism in the RAGE gene relevant to schizophrenia and the personality trait psychoticism?Journal of psychiatry & neuroscience : JPN · 2012Article
- Epigenetic and genetic factors predict women's salivary cortisol following a threat to the social self.PloS one · 2012Article
- Hyperactivity, startle reactivity and cell-proliferation deficits are resistant to chronic lithium treatment in adult Nr2e1(frc/frc) mice.Genes, brain, and behavior · 2010Article
- Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.PloS one · 2009Article
- Genetic, epigenetic and environmental impact on sex differences in social behavior.Physiology & behavior · 2009Review
- Influence of androgen receptor repeat polymorphisms on personality traits in men.Journal of psychiatry & neuroscience : JPN · 2009Article
- Sex steroid-related candidate genes in psychiatric disorders.Journal of psychiatry & neuroscience : JPN · 2008Review
- Mutation and evolutionary analyses identify NR2E1-candidate-regulatory mutations in humans with severe cortical malformations.Genes, brain, and behavior · 2007Article
- Personality traits of agreeableness and extraversion are associated with ADH4 variation.Biological psychiatry · 2007Article
- Individual differences in estrogen receptor alpha in select brain nuclei are associated with individual differences in aggression.Hormones and behavior · 2006Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Estrogens are known to play a key role in the regulation of various aspects of behavior. In order to study the potential contribution of genetic variation in the estrogen receptor (ER) alpha to specific personality traits, we investigated a repeat polymorphism in the ER alpha gene in 172 42-year-old women who had been assessed using the Karolinska Scales of Personality (KSP). Based on the hypothesis that there is a relationship between the length of a repeat polymorphism and gene function,(1) the alleles were divided into two groups: short and long. In order to elucidate the possible influence of the ER alpha gene on the different aspects of personality measured by means of the KSP, the possible association between this gene and four different factors ('neuroticism', 'psychoticism', 'non-conformity', and 'extraversion') was analysed. 'Neuroticism', 'psychoticism', and 'non-conformity' all appeared to be associated with the ER alpha gene. After correction for multiple comparisons by means of permutation analysis, the associations with the factor 'non-conformity'--including the subscales 'indirect aggression' and 'irritability'--and the factor 'psychoticism'--including the subscale 'suspicion'--remained significant. The results suggest that the studied dinucleotide repeat polymorphism of the ER alpha gene may contribute to specific components of personality.
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