ArticleMolecular psychiatry2003
Cathepsin D exon 2 polymorphism associated with general intelligence in a healthy older population.
Article in Molecular psychiatry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Lack of association between cathepsin D C224T polymorphism and Alzheimer's disease risk: an update meta-analysis.BMC neurology · 2014Pooled it
- Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis.Alzheimer's research & therapy · 2024Article
- Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified α-Synuclein Degradation Properties.Frontiers in cell and developmental biology · 2021Article
- Why it is hard to find genes associated with social science traits: theoretical and empirical considerations.American journal of public health · 2013Article
- Common genetic variation and performance on standardized cognitive tests.European journal of human genetics : EJHG · 2010Article
- The impact of genetic research on our understanding of normal cognitive ageing: 1995 to 2009.Neuropsychology review · 2009Review
- Challenges in phenotype definition in the whole-genome era: multivariate models of memory and intelligence.Neuroscience · 2009Review
- Genetic foundations of human intelligence.Human genetics · 2009Review
- TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration.Acta neuropathologica · 2008Article
- Cathepsin D SNP associated with increased risk of variant Creutzfeldt-Jakob disease.BMC medical genetics · 2008Article
- A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.BMC genetics · 2007Article
- Genetic associations between cathepsin D exon 2 C-->T polymorphism and Alzheimer's disease, and pathological correlations with genotype.Journal of neurology, neurosurgery, and psychiatry · 2006Article
- A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability.Molecular psychiatry · 2004Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
General intelligence is a heritable trait that is a risk factor for both the onset of dementia and the rate of cognitive decline in community-dwelling older persons. Previous studies screening for quantitative trait loci (QTLs) that influence general intelligence in healthy individuals have identified four loci, two of which are located within the genes insulin-like growth factor 2 receptor (IGF2R) and the Msx1 homeobox. Here, we report the finding of another QTL associated with general intelligence that is located within exon 2 of the cathepsin D (CTSD) gene. A group of 767 healthy adults with a follow-up period of over 15 years have been analyzed for cross-sectional and longitudinal trends in cognitive change using the Heim intelligence test score (AH4-1). We observed a significant association (P = 0.01) between a functional C > T (Ala > Val) transition within exon 2 of the CTSD gene that increases the secretion of pro-CTSD from the cell, and the AH4-1 score at initial testing on entry to the longitudinal study. Interestingly, CTSD is transported by IGF2R from the trans Golgi network to the lysosome.
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