ArticleMolecular and cellular biology2003
Mouse germ cell-less as an essential component for nuclear integrity.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 81 citations in OpenAlex.
- In situ structure of the mouse sperm central apparatus reveals mechanistic insights into asthenozoospermia.Cell research · 2025Article
- Genome-Wide Identification and Expression Analysis of theInternational journal of molecular sciences · 2024Article
- Regulation of early spermatogenesis in the giant prawn Macrobrachium rosenbergii by a GCL homolog†.Biology of reproduction · 2024Article
- The Role of Lamins in the Nucleoplasmic Reticulum, a Pleiomorphic Organelle That Enhances Nucleo-Cytoplasmic Interplay.Frontiers in cell and developmental biology · 2022Review
- Towards Post-Meiotic Sperm Production: Genetic Insight into Human Infertility from Mouse Models.International journal of biological sciences · 2021Review
- The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review.Basic and clinical andrology · 2018Article
- GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK.Developmental cell · 2017Article
- The Acrosomal Matrix.Advances in anatomy, embryology, and cell biology · 2016Review
- Transcriptome profiles of Penaeus (Marsupenaeus) japonicus animal and vegetal half-embryos: identification of sex determination, germ line, mesoderm, and other developmental genes.Marine biotechnology (New York, N.Y.) · 2015Article
- The nuclear form of glutathione peroxidase 4 colocalizes and directly interacts with protamines in the nuclear matrix during mouse sperm chromatin assembly.Spermatogenesis · 2014Article
- A spindle-independent cleavage pathway controls germ cell formation in Drosophila.Nature cell biology · 2013Article
- Chromatin remodelling initiation during human spermiogenesis.Biology open · 2012Article
- CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy.Circulation research · 2012Article
- GAGE cancer-germline antigens are recruited to the nuclear envelope by germ cell-less (GCL).PloS one · 2012Article
- Functions of PIWI proteins in spermatogenesis.Clinical and experimental reproductive medicine · 2011Article
- A conserved germline multipotency program.Development (Cambridge, England) · 2010Article
- Contributions of extracellular matrix signaling and tissue architecture to nuclear mechanisms and spatial organization of gene expression control.Biochimica et biophysica acta · 2009Review
- Article
- Depletion of nucleophosmin leads to distortion of nucleolar and nuclear structures in HeLa cells.The Biochemical journal · 2008Article
- The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression.Nature genetics · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A mouse homologue of the Drosophila melanogaster germ cell-less (mgcl-1) gene is expressed ubiquitously, and its gene product is localized to the nuclear envelope based on its binding to LAP2 beta (lamina-associated polypeptide 2 beta). To elucidate the role of mgcl-1, we analyzed two mutant mouse lines that lacked mgcl-1 gene expression. Abnormal nuclear morphologies that were probably due to impaired nuclear envelope integrity were observed in the liver, exocrine pancreas, and testis. In particular, functional abnormalities were observed in testis in which the highest expression of mgcl-1 was detected. Fertility was significantly impaired in mgcl-1-null male mice, probably as a result of severe morphological abnormalities in the sperm. Electron microscopic observations showed insufficient chromatin condensation and abnormal acrosome structures in mgcl-1-null sperm. In addition, the expression patterns of transition proteins and protamines, both of which are essential for chromatin remodeling during spermatogenesis, were aberrant. Considering that the first abnormality during the process of spermatogenesis was abnormal nuclear envelope structure in spermatocytes, the mgcl-1 gene product appears to be essential for appropriate nuclear-lamina organization, which in turn is essential for normal sperm morphogenesis and chromatin remodeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.