ArticleMolecular and cellular biology2003
Impaired hepatocyte DNA synthetic response posthepatectomy in insulin-like growth factor binding protein 1-deficient mice with defects in C/EBP beta and mitogen-activated protein kinase/extracellular signal-regulated kinase regulation.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 107 citations in OpenAlex.
- Review
- Role of mitogens in normal and pathological liver regeneration.Hepatology communications · 2025Review
- Mice with gene alterations in the GH and IGF family.Pituitary · 2022Review
- Liver regeneration biology: Implications for liver tumour therapies.World journal of clinical oncology · 2021Review
- Review
- IGFBP-1 in Cardiometabolic Pathophysiology-Insights From Loss-of-Function and Gain-of-Function Studies in Male Mice.Journal of the Endocrine Society · 2020Article
- The insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes.Molecular metabolism · 2019Review
- IGF-Binding Proteins: Why Do They Exist and Why Are There So Many?Frontiers in endocrinology · 2018Review
- IGFBP1 increases β-cell regeneration by promoting α- to β-cell transdifferentiation.The EMBO journal · 2016Article
- Induction and contribution of beta platelet-derived growth factor signalling by hepatic stellate cells to liver regeneration after partial hepatectomy in mice.Liver international : official journal of the International Association for the Study of the Liver · 2016Article
- A novel comparative pattern analysis approach identifies chronic alcohol mediated dysregulation of transcriptomic dynamics during liver regeneration.BMC genomics · 2016Article
- Transcriptomic characterization of the dorsal lobes after hepatectomy of the ventral lobe in zebrafish.BMC genomics · 2015Article
- A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption.Cell metabolism · 2015Article
- Hepatic stellate cell-expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage.EMBO molecular medicine · 2015Article
- Genomics of liver transplant injury and regeneration.Transplantation reviews (Orlando, Fla.) · 2015Review
- Maternal nutritional history modulates the hepatic IGF-IGFBP axis in adult male rat offspring.Endocrine · 2014Article
- Identification of metabolites, clinical chemistry markers and transcripts associated with hepatotoxicity.PloS one · 2014Article
- Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Archives of toxicology · 2013Review
- The p53 Codon 72 Polymorphism Modifies the Cellular Response to Inflammatory Challenge in the Liver.Journal of liver · 2013Article
- Amphiregulin stimulates liver regeneration after small-for-size mouse liver transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
After a two-thirds hepatectomy, normally quiescent liver cells are stimulated to reenter the cell cycle and proliferate to restore the original liver mass. One of the most rapidly and highly induced genes and proteins in regenerating liver is insulin-like growth factor binding protein 1 (IGFBP-1), a secreted protein that may modulate the activities of insulin-like growth factors (IGFs) or signal via IGF-independent mechanisms. To assess the functional role of IGFBP-1 in liver regeneration, mice with a targeted disruption of the IGFBP-1 gene were generated. Although IGFBP-1(-/-) mice demonstrated normal development, they had abnormal liver regeneration after partial hepatectomy, characterized by liver necrosis and reduced and delayed hepatocyte DNA synthesis. The abnormal regenerative response was associated with blunted activation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and a reduced induction of C/EBP beta protein expression posthepatectomy. Like cell cycle abnormalities observed in hepatectomized C/EBP beta(-/-) mice, cyclin A and cyclin B1 expression was delayed and reduced in IGFBP-1(-/-) livers, whereas cyclin D1 expression was normal. Treatment of IGFBP-1(-/-) mice with a preoperative dose of IGFBP-1 induced MAPK/ERK activation and C/EBP beta expression, suggesting that IGFBP-1 may support liver regeneration at least in part via its effect on MAPK/ERK and C/EBP beta activities. These findings are the first demonstration of the involvement of IGFBP-1 in the regulation of in vivo mitogenic signaling pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.