Evidence map›Paper›PMID 12555267›Full record

ArticleJournal of neurobiology2003

Vitamin A deficiency leads to increased cell proliferation in olfactory epithelium of mature rats.

M A Asson-Batres, M-S Zeng, V Savchenko, A Aderoju, J McKanna

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurobiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

  1. Vitamin A-Containing Intranasal Drops Improve Odour Detection Threshold.ORL; journal for oto-rhino-laryngology and its related specialties · 2026
    Article
  2. Article
  3. Intranasal vitamin A is beneficial in post-infectious olfactory loss.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017
    Article
  4. Effects of vitamin A deficiency in the postnatal mouse heart: role of hepatic retinoid stores.American journal of physiology. Heart and circulatory physiology · 2016
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The neurobiology of retinoic acid in affective disorders.Progress in neuro-psychopharmacology & biological psychiatry · 2008
    Review
  11. Article
  12. Retinoic acid receptor-dependent survival of olfactory sensory neurons in postnatal and adult mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

M A Asson-BatresDepartment of Biological Sciences, Tennessee State University, P.O. Box 1116, 3500 John A. Merritt Blvd., Nashville, Tennessee 37209, USA. massonbatres@tnstate.edu
M-S Zeng
V Savchenko
A Aderoju
J McKanna
Tennessee State University · USVanderbilt University · US

Funding

VITAMIN A STATUS--INFLUENCE ON GENE EXPRESSION PATTERNS IN ADULT NEURAL TISSUESS06GM008092 · NIGMS · TENNESSEE STATE UNIVERSITY · PI ASSON-BATRES, MARY ANN · 1989 to 2010
$5.0M
VITAMIN A STATUS/EFFECTS ON OLFACTORY NEURON MATURATIONK02DC000180 · NIDCD · TENNESSEE STATE UNIVERSITY · PI ASSON-BATRES, MARY ANN · 2000 to 2004
$381k
NIDCD NIH HHS 5 KO2 DC00180-02NIDCD NIH HHS K02 DC000180NIGMS NIH HHS S06 GM008092NIGMS NIH HHS S-06-GM-08092
6 · The paper itself

Abstract

We have shown previously that vitamin A deficiency (VAD) leads to the decreased expression of gene products that are specifically synthesized by mature neurons in the olfactory epithelium (OE) of adult rats. These results support the hypothesis that retinoic acid, a derivative of vitamin A, is required for neurogenesis and neuron replacement in vivo. VAD does not cause gross degeneration of the OE, raising the question: what types of cells continue to populate VAD OE? In this study, we compared the cell densities of VAD and VA-sufficient (VAS) OE and investigated whether cell proliferation is upregulated in VAD OE. The results show that (1) total cell number in VAD and VAS OE are comparable; (2) localized areas of hyperplasia are present in the basal regions of VAD, but not VAS, OE; (3) there is a substantial increase in the number of PCNA (proliferating cell nuclear antigen) positive cells in the basal region of VAD OE relative to VAS OE; and (4) there is a relative increase in the levels of mRNA encoding the transcription factor, MASH I, in VAD OE. We conclude that reduced availability of vitamin A derivatives, such as retinoic acid, leads to a loss of control over proliferation, hyperplasia, and increased numbers of pro-neural cells in vivo.

Indexed as

AnimalsAnimals, NewbornBasic Helix-Loop-Helix ProteinsCell CountCell DivisionDNA-Binding ProteinsImmunohistochemistryIn Situ HybridizationMaleNerve Tissue ProteinsOlfactory Marker ProteinOlfactory MucosaProliferating Cell Nuclear AntigenRandom AllocationRatsRats, Sprague-DawleyAscl1 protein, ratBasic Helix-Loop-Helix ProteinsDNA-Binding ProteinsNerve Tissue ProteinsOlfactory Marker ProteinOmp protein, ratProliferating Cell Nuclear AntigenRNA, MessengerRNA, Ribosomal, 18STranscription Factors

Identifiers

PMID12555267
PMCPMC3223104
OpenAlexW1970401714

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.