ArticleOncogene2003
AXIN1 mutations but not deletions in cerebellar medulloblastomas.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 147 citations in OpenAlex.
- Imaging Characteristics of Wingless Pathway Subgroup Medulloblastomas: Results from the German HIT/SIOP-Trial Cohort.AJNR. American journal of neuroradiology · 2019Article
- Medulloblastoma, WNT-activated/SHH-activated: clinical impact of molecular analysis and histogenetic evaluation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Review
- Article
- Emergence of TNIK inhibitors in cancer therapeutics.Cancer science · 2017Review
- WNT signaling in glioblastoma and therapeutic opportunities.Laboratory investigation; a journal of technical methods and pathology · 2016Review
- Immunobiology and signaling pathways of cancer stem cells: implication for cancer therapy.Cytotechnology · 2015Article
- Biflavone Ginkgetin, a Novel Wnt Inhibitor, Suppresses the Growth of Medulloblastoma.Natural products and bioprospecting · 2015Article
- Analysis of chromosome 17 miRNAs and their importance in medulloblastomas.BioMed research international · 2015Review
- AXIN1 and AXIN2 variants in gastrointestinal cancers.Cancer letters · 2014Review
- Signaling pathway and molecular subgroups of medulloblastoma.International journal of clinical and experimental pathology · 2013Review
- WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation.PloS one · 2013Article
- CTNNB1, AXIN1 and APC expression analysis of different medulloblastoma variants.Clinics (Sao Paulo, Brazil) · 2013Article
- Medulloblastomics: the end of the beginning.Nature reviews. Cancer · 2012Review
- Gene expression by simian virus 40 large T antigen-induced medulloblastomas in mice.Neural regeneration research · 2012Article
- The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients.Genome research · 2012Article
- Activation of Wnt/β-catenin signalling affects differentiation of cells arising from the cerebellar ventricular zone.PloS one · 2012Article
- Dishevelled 2 signaling promotes self-renewal and tumorigenicity in human gliomas.Cancer research · 2011Article
- Molecular diagnostics in embryonal brain tumors.Brain pathology (Zurich, Switzerland) · 2011Review
- The perivascular niche microenvironment in brain tumor progression.Cell cycle (Georgetown, Tex.) · 2010Review
- Reduced beta-catenin expression is associated with good prognosis in Astrocytoma.Pathology oncology research : POR · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medulloblastoma is a malignant, invasive embryonal tumour of the cerebellum which manifests preferentially in children. A subset of cases is associated with colon cancer and APC germline mutations (Turcot syndrome), and APC and beta-catenin point mutations occur in up to 10% of sporadic cases, indicating the involvement of the Wnt pathway in the development of medulloblastoma. In 39 sporadic cerebellar medulloblastomas screeened for alterations in the AXIN1 gene, another component of the Wnt pathway, we found missense AXIN1 mutations in two tumours, CCC-->TCC at codon 255 (exon 1, Pro-->Ser) and TCT-->TGT at codon 263 (exon 1, Ser-->Cys). Furthermore, the A allele at the G/A polymorphism at nucleotide 16 in intron 4 was significantly over-represented in medulloblastomas (39 cases; G 0.76 vs-A 0.24) compared to healthy individuals (86 cases; G 0.91 vs A 0.09; P=0.0027). RT-PCR revealed large deletions in the AXIN1 gene in 5/12 (42%) medulloblastomas, consistent with a previous report. However, we observed such deletions at a similar frequency also in normal brain tissue (6/12, 50%). Since there are multiple complementary, inverted sequences present in the AXIN1 gene, these large deletions may represent RT-PCR errors due to stem-loop secondary structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.