ArticleOncogene2003
Ambivalent role of BCL6 in cell survival and transformation.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the Eμ-miR-155 transgenic mouse model.Proceedings of the National Academy of Sciences of the United States of America · 2012Pooled it
- Validation of MYC and BCL6 rapid break apart digital fluorescence in situ hybridization assays for clinical use.International journal of clinical and experimental pathology · 2023Article
- Regulation of T Helper Cell Fate by TCR Signal Strength.Frontiers in immunology · 2020Review
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- Unraveling Tumor Heterogeneity in an Apparently Monolithic Disease: BCL2 and Other Players in the Genetic Landscape of Nodal Follicular Lymphoma.Frontiers in medicine · 2019Review
- Characterizing Atypical BCL6 Signal Patterns Detected by Digital Fluorescence In Situ Hybridization (FISH) Analysis.Annals of laboratory medicine · 2018Article
- STAT5 is essential for IL-7-mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells.Blood advances · 2018Article
- Homoharringtonine suppresses imatinib resistance via the Bcl-6/p53 pathway in chronic myeloid leukemia cell lines.Oncotarget · 2017Article
- Characterization of adipose-derived stem cells from subcutaneous and visceral adipose tissues and their function in breast cancer cells.Oncotarget · 2015Article
- Zinc finger and BTB domain-containing protein 3 is essential for the growth of cancer cells.BMB reports · 2014Article
- Bcl6a function is required during optic cup formation to prevent p53-dependent apoptosis and colobomata.Human molecular genetics · 2013Article
- Comparative gene expression profiling of placentas from patients with severe pre-eclampsia and unexplained fetal growth restriction.Reproductive biology and endocrinology : RB&E · 2011Article
- BCL6 canalizes Notch-dependent transcription, excluding Mastermind-like1 from selected target genes during left-right patterning.Developmental cell · 2010Article
- BCL6-mediated attenuation of DNA damage sensing triggers growth arrest and senescence through a p53-dependent pathway in a cell context-dependent manner.The Journal of biological chemistry · 2008Article
- Article
- EPO modulation of cell-cycle regulatory genes, and cell division, in primary bone marrow erythroblasts.Blood · 2007Article
- The pupal specifier broad directs progressive morphogenesis in a direct-developing insect.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- A new description of cellular quiescence.PLoS biology · 2006Article
- Insights into gene expression changes impacting B-cell transformation: cross-species microarray analysis of bovine leukemia virus tax-responsive genes in ovine B cells.Journal of virology · 2006Article
- ZENON, a novel POZ Kruppel-like DNA binding protein associated with differentiation and/or survival of late postmitotic neurons.Molecular and cellular biology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The BCL6 gene is often structurally altered and probably 'misregulated' in two different types of human B-cell non-Hodgkin lymphomas (BNHL) thought to arise from germinal centre B cells. BCL6 encodes a BTB/POZ and zinc finger protein whose biochemical properties support a role as a DNA-binding transcriptional repressor and disclose, in part, the underlying mechanisms. In contrast, the study of the 'oncogenic' structural alterations of BCL6 in BNHL and of its cellular functions gives rise to much more heterogeneous data with no obvious unifying picture so that how and even whether BCL6 contributes to lymphomagenesis remains unclear. This review will summarize the current knowledge about the 'oncogenic' alterations and cellular functions of BCL6 and, based on some results, will propose the following hypotheses: (1) In various systems, including in memory T cells and also in germinal centre B cells and possibly in certain postmitotic cells, BCL6 may act by stabilizing a particular stage of differentiation. (2) Both its ambivalent effects on cell survival and the heterogeneous consequences of its alterations in BNHL suggest that BCL6 can be oncogenic not only upon overexpression or persistent expression, as often proposed, but also, similar to some of its relatives, upon 'accidental' downregulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.