ArticleOccupational and environmental medicine2003
Occupational silica exposure and risk of various diseases: an analysis using death certificates from 27 states of the United States.
Article in Occupational and environmental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 7 syntheses or guidelines pooled it, 273 citations in OpenAlex.
- AWMF S2k Guideline: Diagnosis and Assessment of Lung Disease Caused by Occupational Silica Dust Exposure (Silicosis) - Disease No. 4101 as per Occupational Diseases Ordinance (BKV) Annex 1.Respiration; international review of thoracic diseases · 2026Guideline
- Occupational exposure to toxic particles and risk of pulmonary sarcoidosis: a systematic review and meta-analysis.BMJ open respiratory research · 2026Pooled it
- Occupational exposures and sarcoidosis: a rapid review of the evidence.Occupational medicine (Oxford, England) · 2024Pooled it
- Systematic Review and Meta-analysis on the Association of Occupational Exposure to Free Crystalline Silica and Rheumatoid Arthritis.Clinical reviews in allergy & immunology · 2022Pooled it
- Occupational exposure to respirable crystalline silica and chronic non-malignant renal disease: systematic review and meta-analysis.International archives of occupational and environmental health · 2017Pooled it
- Occupational and environmental scleroderma. Systematic review and meta-analysis.Clinical rheumatology · 2017Pooled it
- Occupational silica exposure as a risk factor for scleroderma: a meta-analysis.International archives of occupational and environmental health · 2010Pooled it
- Deciphering Pathogenesis of Silica Nanoparticle-Induced Airway Remodeling and Fibrosis: Insights from a Human Patient Cohort and a Murine Model.Nanomaterials (Basel, Switzerland) · 2026Article
- Web application development using multiple regression analysis to predict silicosis risk among stone carvers in Nakhon Ratchasima, Thailand.Journal of occupational medicine and toxicology (London, England) · 2026Article
- Caplan Syndrome: A Case Report.Clinical case reports · 2026Article
- Chemical Exposure Assessment in Traditional Korean Pottery Workplaces.Safety and health at work · 2025Article
- Investigation of factors influencing abnormal pulmonary ventilation function in occupational exposed populations and the establishment of a risk prediction model.Scientific reports · 2024Article
- Silicotuberculosis: a critical narrative review.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Treatment Outcomes of Tuberculosis Among Artisanal and Small-Scale Miners in Zimbabwe: A Follow-Up Observational Study Using Secondary Data.International journal of environmental research and public health · 2024Observational
- Latent tuberculosis infection and infection-associated risk factors for miner workers with silicosis in eastern China.BMC pulmonary medicine · 2024Article
- Risk of mycobacterial infections in a cohort of silicosis patients with autoimmune rheumatic diseases.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024Article
- Silicosis Incidence and Mortality after Occupational Exposure with Silica Dust: A Systematic Review and Dose-Response Meta-Analysis.Medical journal of the Islamic Republic of Iran · 2024Review
- Exploring the Impact of Silicosis Incidence on Tuberculosis Mortality and Morbidity: A Multi-Country Study.Medical sciences (Basel, Switzerland) · 2023Article
- A Descriptive Study of a Turkish Pneumoconiosis Case-Series.La Medicina del lavoro · 2023Article
- Evaluation of Lung Functions, Blood Pressure, and Hearing Deterioration in Tile Setters.Cureus · 2023Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough crystalline silica exposure is associated with silicosis, lung cancer, pulmonary tuberculosis, and chronic obstructive pulmonary disease (COPD), there is less support for an association with autoimmune disease, and renal disease.
methodsUsing data from the US National Occupational Mortality Surveillance (NOMS) system, a matched case-control design was employed to examine each of several diseases (including silicosis, lung cancer, stomach cancer, oesophageal cancer, COPD, pulmonary tuberculosis, sarcoidosis, systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, and various types of renal disease). Cases were subjects whose death certificate mentioned the disease of interest. A separate control group for each of the diseases of interest was selected from among subjects whose death certificate did not mention the disease of interest or any of several diseases reported to be associated with crystalline silica exposure. Subjects were assigned into a qualitative crystalline silica exposure category based on the industry/occupation pairing found on their death certificate. We also investigated whether silicotics had a higher risk of disease compared to those without silicosis.
resultsThose postulated to have had detectable crystalline silica exposure had a significantly increased risk for silicosis, COPD, pulmonary tuberculosis, and rheumatoid arthritis. In addition, a significant trend of increasing risk with increasing silica exposure was observed for these same conditions and for lung cancer. Those postulated to have had the greatest crystalline silica exposure had a significantly increased risk for silicosis, lung cancer, COPD, and pulmonary tuberculosis only. Finally, those with silicosis had a significantly increased risk for COPD, pulmonary tuberculosis, and rheumatoid arthritis.
conclusionsThis study corroborates the association between crystalline silica exposure and silicosis, lung cancer, COPD, and pulmonary tuberculosis. In addition, support is provided for an association between crystalline silica exposure and rheumatoid arthritis.
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