ArticleThe EMBO journal2003
Chromatin exposes intrinsic differences in the transcriptional activities of estrogen receptors alpha and beta.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Pooled it
- Association between polymorphisms in the estrogen receptor alpha gene and osteoarthritis susceptibility: a meta-analysis.BMC musculoskeletal disorders · 2015Pooled it
- Diarylpropionitrile, a selective agonist of estrogen receptor β, protects the kidney against ischemia-reperfusion injury and enhances the repair of tubular epithelial cells.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- MiR-203 regulates estrogen receptor α and cartilage degradation in IL-1β-stimulated chondrocytes.Journal of bone and mineral metabolism · 2020Article
- Sequence variations in estrogen receptor 1 and 2 genes and their association with egg production traits in Chinese Dagu chickens.The Journal of veterinary medical science · 2017Article
- Association between estrogen receptor-alpha gene PvuII and XbaI polymorphisms and osteoarthritis risk: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Histone deacetylase inhibition induces long-lasting changes in maternal behavior and gene expression in female mice.Endocrinology · 2014Article
- Hormone-regulated transcriptomes: lessons learned from estrogen signaling pathways in breast cancer cells.Molecular and cellular endocrinology · 2014Review
- Association of single nucleotide polymorphisms in estrogen receptor alpha gene with susceptibility to knee osteoarthritis: a case-control study in a Chinese Han population.BioMed research international · 2014Article
- Experience-facilitated improvements in pup retrieval; evidence for an epigenetic effect.Hormones and behavior · 2012Article
- Analysis of estrogen receptor alpha gene haplotype in Mexican mestizo patients with primary osteoarthritis of the knee.Rheumatology international · 2012Article
- Neuromodulation by soy diets or equol: anti-depressive & anti-obesity-like influences, age- & hormone-dependent effects.BMC neuroscience · 2011Article
- Coactivation of estrogen receptor beta by gonadotropin-induced cofactor GIOT-4.Molecular and cellular biology · 2009Article
- Review
- Article
- Review
- Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription.The EMBO journal · 2006Article
- Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor.Molecular endocrinology (Baltimore, Md.) · 2006Article
- ERalpha and ERbeta expression and transcriptional activity are differentially regulated by HDAC inhibitors.Oncogene · 2006Article
- Altered pharmacology and distinct coactivator usage for estrogen receptor-dependent transcription through activating protein-1.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The biological actions of estrogens are mediated via two distinct intranuclear estrogen receptor (ER) proteins, ERalpha and ERbeta. We have used an in vitro chromatin assembly and transcription system to compare the transcriptional activities of the two ERs in the context of chromatin, the physiological template for transcription by RNA polymerase II. We find that under conditions where many biochemical activities of the receptors are similar (e.g. ligand binding, chromatin binding, chromatin remodeling and co-activator recruitment), liganded ERalpha is a much more potent transcriptional activator than ERbeta with chromatin templates, but not with naked DNA. This difference is attributable to the N-terminal A/B region of ERalpha, which contains a transferable activation function that facilitates transcription specifically with chromatin templates. Interestingly, chromatin selectively restricts ligand-dependent transcriptional activation by ERbeta under some conditions (e.g. with a closed chromatin architecture), while allowing it under other conditions (e.g. with an open chromatin architecture). Collectively, our results define an important role for chromatin in determining signaling outcomes mediated by distinct subtypes of signal-transducing transcriptional activator proteins.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.