ArticleThe EMBO journal2003
Regulation of light-dependent Gqalpha translocation and morphological changes in fly photoreceptors.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Two lysosomal genes ATP13A2 and GBA1 interact to drive neurodegeneration.Molecular neurodegeneration · 2026Article
- Decoding the Functional Interactome of Non-Model Organisms with PHILHARMONIC.bioRxiv : the preprint server for biology · 2025Article
- Circadian rhythms in the Drosophila eye may regulate adaptation of vision to light intensity.Frontiers in neuroscience · 2024Article
- Visual and circadian regulation ofiScience · 2023Article
- A Quantitative Model of Sporadic Axonal Degeneration in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation.The EMBO journal · 2019Article
- A Single Residue Mutation in the GαG3 (Bethesda, Md.) · 2018Article
- CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells.Journal of cell science · 2016Article
- Article
- Opsin1-2, G(q)α and arrestin levels at Limulus rhabdoms are controlled by diurnal light and a circadian clock.The Journal of experimental biology · 2013Article
- Depletion of PtdIns(4,5)P₂ underlies retinal degeneration in Drosophila trp mutants.Journal of cell science · 2013Article
- Stochastic, adaptive sampling of information by microvilli in fly photoreceptors.Current biology : CB · 2012Article
- Drosophila visual transduction.Trends in neurosciences · 2012Review
- PDA (prolonged depolarizing afterpotential)-defective mutants: the story of nina's and ina's--pinta and santa maria, too.Journal of neurogenetics · 2012Review
- Phospholipase C-mediated suppression of dark noise enables single-photon detection in Drosophila photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- G protein trafficking.Sub-cellular biochemistry · 2012Review
- Mechanisms underlying stage-1 TRPL channel translocation in Drosophila photoreceptors.PloS one · 2012Article
- Dynamin- and Rab5-dependent endocytosis is required to prevent Drosophila photoreceptor degeneration.Journal of cell science · 2011Article
- Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling.BMC structural biology · 2011Article
- An N-terminal polybasic motif of Gαq is required for signaling and influences membrane nanodomain distribution.Molecular pharmacology · 2010Article
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Authors and funding
8 authors.
Funding
Abstract
Heterotrimeric G-proteins relay signals between membrane-bound receptors and downstream effectors. Little is known, however, about the regulation of Galpha subunit localization within the natural endogenous environment of a specialized signaling cell. Here we show, using live Drosophila flies, that light causes massive and reversible translocation of the visual Gqalpha to the cytosol, associated with marked architectural changes in the signaling compartment. Molecular genetic dissection together with detailed kinetic analysis enabled us to characterize the translocation cycle and to unravel how signaling molecules that interact with Gqalpha affect these processes. Epistatic analysis showed that Gqalpha is necessary but not sufficient to bring about the morphological changes in the signaling organelle. Furthermore, mutant analysis indicated that Gqbeta is essential for targeting of Gqalpha to the membrane and suggested that Gqbeta is also needed for efficient activation of Gqalpha by rhodopsin. Our results support the 'two-signal model' hypothesis for membrane targeting in a living organism and characterize the regulation of both the activity-dependent Gq localization and the cellular architectural changes in Drosophila photoreceptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.