ArticleThe EMBO journal2003
Two distinct myosin light chain structures are induced by specific variations within the bound IQ motifs-functional implications.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 77 citations in OpenAlex.
- Molecular features of myosin F adapted for driving actin flows in Toxoplasma gondii.Journal of cell science · 2026Article
- Myosin 2 drives actin contractility in fast-crawling species outside of the amorphean lineage.Current biology : CB · 2025Article
- Regulatory Light Chains in Cardiac Development and Disease.International journal of molecular sciences · 2021Review
- Calcium absorption in the fluted giant clam, Tridacna squamosa, may involve a homolog of voltage-gated calcium channel subunit α1 (CACNA1) that has an apical localization and displays light-enhanced protein expression in the ctenidium.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- Bi-allelic mutations in MYL1 cause a severe congenital myopathy.Human molecular genetics · 2018Article
- Regulation of class V myosin.Cellular and molecular life sciences : CMLS · 2018Review
- IQGAP1 Binds to Yes-associated Protein (YAP) and Modulates Its Transcriptional Activity.The Journal of biological chemistry · 2016Article
- Myosin‑II heavy chain and formin mediate the targeting of myosin essential light chain to the division site before and during cytokinesis.Molecular biology of the cell · 2015Article
- Structure of myosin-1c tail bound to calmodulin provides insights into calcium-mediated conformational coupling.Nature structural & molecular biology · 2015Article
- Crystal structure of calcium binding protein-5 from Entamoeba histolytica and its involvement in initiation of phagocytosis of human erythrocytes.PLoS pathogens · 2014Article
- Myosin light chains: Teaching old dogs new tricks.Bioarchitecture · 2014Review
- Surface dynamics in allosteric regulation of protein-protein interactions: modulation of calmodulin functions by Ca2+.PLoS computational biology · 2013Article
- Structural basis for the modulation of the neuronal voltage-gated sodium channel NaV1.6 by calmodulin.Scientific reports · 2013Article
- Structure of androcam supports specialized interactions with myosin VI.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Calmodulin bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5a.The Journal of biological chemistry · 2012Article
- A novel Myosin essential light chain mutation causes hypertrophic cardiomyopathy with late onset and low expressivity.Biochemistry research international · 2012Article
- Structural and energetic determinants of apo calmodulin binding to the IQ motif of the Na(V)1.2 voltage-dependent sodium channel.Structure (London, England : 1993) · 2011Article
- MDR1 function is sensitive to the phosphorylation state of myosin regulatory light chain.Biochemical and biophysical research communications · 2010Article
- Variations at the semiconserved glycine in the IQ domain consensus sequence have a major impact on Ca2+-dependent switching in calmodulin-IQ domain complexes.Biochemistry · 2010Article
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
IQ motifs are widespread in nature. Mlc1p is a calmodulin-like myosin light chain that binds to IQ motifs of a class V myosin, Myo2p, and an IQGAP-related protein, Iqg1p, playing a role in polarized growth and cytokinesis in Saccharomyces cerevisiae. The crystal structures of Mlc1p bound to IQ2 and IQ4 of Myo2p differ dramatically. When bound to IQ2, Mlc1p adopts a compact conformation in which both the N- and C-lobes interact with the IQ motif. However, in the complex with IQ4, the N-lobe no longer interacts with the IQ motif, resulting in an extended conformation of Mlc1p. The two light chain structures relate to two distinct subfamilies of IQ motifs, one of which does not interact with the N-lobes of calmodulin-like light chains. The correlation between light chain structure and IQ sequence is demonstrated further by sedimentation velocity analysis of complexes of Mlc1p with IQ motifs from Myo2p and Iqg1p. The resulting 'free' N-lobes of myosin light chains in the extended conformation could mediate the formation of ternary complexes during protein localization and/or partner recruitment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.