ArticleThe Biochemical journal2003
Attenuation of glucocorticoid functions in an Anx-A1-/- cell line.
Article in The Biochemical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 65 citations in OpenAlex.
- Review
- A single-center analysis of visual outcomes and associated factors after intravenous methylprednisolone treatment for dysthyroid optic neuropathy.BMC ophthalmology · 2023Article
- Annexin Animal Models-From Fundamental Principles to Translational Research.International journal of molecular sciences · 2021Review
- The Anti-allergic Cromones: Past, Present, and Future.Frontiers in pharmacology · 2017Review
- Downregulation of Annexin A1 by short hairpin RNA inhibits the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells.International journal of molecular medicine · 2015Article
- Localization of annexins A1 and A2 in the respiratory tract of healthy calves and those experimentally infected with Mannheimia haemolytica.Veterinary research · 2015Article
- Article
- Identification of tumour-related proteins as potential screening markers by proteome analysis-protein profiles of human saliva as a predictive and prognostic tool.The EPMA journal · 2014Article
- Annexin A1: potential for glucocorticoid sparing in RA.Nature reviews. Rheumatology · 2013Review
- Epithelial-specific deletion of 11β-HSD2 hinders Apcmin/+ mouse tumorigenesis.Molecular cancer research : MCR · 2013Article
- Article
- Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis.BMC immunology · 2011Article
- Candida-host interactions in HIV disease: implications for oropharyngeal candidiasis.Advances in dental research · 2011Review
- Annexin-A1 identified as the oral epithelial cell anti-Candida effector moiety.Molecular oral microbiology · 2010Article
- The annexins: spatial and temporal coordination of signaling events during cellular stress.Cellular and molecular life sciences : CMLS · 2009Review
- Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1.Biochemical pharmacology · 2009Article
- Annexin-A1: a pivotal regulator of the innate and adaptive immune systems.British journal of pharmacology · 2008Review
- Impaired phagocytic mechanism in annexin 1 null macrophages.British journal of pharmacology · 2006Article
- EGF stimulates annexin 1-dependent inward vesiculation in a multivesicular endosome subpopulation.The EMBO journal · 2006Article
- Glucocorticoids: exemplars of multi-tasking.British journal of pharmacology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Ca(2+)- and phospholipid-binding protein Anx-A1 (annexin 1; lipocortin 1) has been described both as an inhibitor of phospholipase A(2) (PLA(2)) activity and as a mediator of glucocorticoid-regulated cell growth and eicosanoid generation. Here we show that, when compared with Anx-A1(+/+) cells, lung fibroblast cell lines derived from the Anx-A1(-/-) mouse exhibit an altered morphology characterized by a spindle-shaped appearance and an accumulation of intracellular organelles. Unlike their wild-type counterparts, Anx-A1(-/-) cells also overexpress cyclo-oxygenase 2 (COX 2), cytosolic PLA(2) and secretory PLA(2) and in response to fetal calf serum, exhibit an exaggerated release of eicosanoids, which is insensitive to dexamethasone (10(-8)- 10(-6) M) inhibition. Proliferation and serum-induced progression of Anx-A1(+/+) cells from G(0)/G(1) into S phase, and the associated expression of extracellular signal-regulated kinase 2 (ERK2), cyclin-dependent kinase 4 (cdk4) and COX 2, is strongly inhibited by dexamethasone, whereas Anx-A1(-/-) cells are refractory to the drug. Loss of the response to dexamethasone in Anx-A1(-/-) cells occurs against a background of no apparent change in glucocorticoid receptor expression or sensitivity to non-steroidal anti-inflammatory drugs. Taken together, these observations suggest strongly that Anx-A1 functions as an inhibitor of signal-transduction pathways that lead to cell proliferation and may help to explain how glucocorticoids regulate these processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.