ArticleClinical & experimental metastasis2002
Role of integrin alpha(v)beta3 in the early phase of liver metastasis: PET and IVM analyses.
Article in Clinical & experimental metastasis, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Exosomal integrin αvβ3 derived from colorectal cancer promotes the liver pre-metastatic niche formation by inducing cancer-associated fibroblasts activation.Clinical and experimental medicine · 2026Article
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- Investigation of the essential role of platelet-tumor cell interactions in metastasis progression using an agent-based model.Theoretical biology & medical modelling · 2014Article
- Prognostic value of β1 integrin expression in colorectal liver metastases.International journal of clinical and experimental pathology · 2014Article
- Crossing the endothelial barrier during metastasis.Nature reviews. Cancer · 2013Review
- Regulation of integrin αV subunit expression by sulfatide in hepatocellular carcinoma cells.Journal of lipid research · 2013Article
- Mechanisms regulating colorectal cancer cell metastasis into liver (Review).Oncology letters · 2012Article
- αV integrins in angiogenesis and cancer.Cold Spring Harbor perspectives in medicine · 2011Review
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- In vivo tumor cell adhesion in the pulmonary microvasculature is exclusively mediated by tumor cell--endothelial cell interaction.BMC cancer · 2010Article
- Integrin alpha2 mediates selective metastasis to the liver.Cancer research · 2009Article
- Interactions between colon cancer cells and hepatocytes in rats in relation to metastasis.Journal of cellular and molecular medicine · 2008Article
- Integrins as antimetastatic targets of RGD-independent snake venom components in liver metastasis [corrected].Neoplasia (New York, N.Y.) · 2008Article
- In vivo models for early development of colorectal liver metastasis.International journal of experimental pathology · 2008Review
- The tumor cell-host organ interface in the early onset of metastatic organ colonisation.Clinical & experimental metastasis · 2008Review
- Adhesion molecules and chemokines: the navigation system for circulating tumor (stem) cells to metastasize in an organ-specific manner.Clinical & experimental metastasis · 2008Review
- Establishment and characterization of a high metastatic potential in the peritoneum for human gastric cancer by orthotopic tumor cell implantation.Digestive diseases and sciences · 2007Article
- Organ-specific metastatic tumor cell adhesion and extravasation of colon carcinoma cells with different metastatic potential.The American journal of pathology · 2006Article
- Expression of ADAM15 in lung carcinomas.Virchows Archiv : an international journal of pathology · 2005Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To clarify the function of integrin alpha(v)beta3 in the early stage of liver metastasis, we investigated the interactions of metastatic cells with their target organ under the actual blood flow by using positron emission tomography (PET). The cells used were CHO-K1 cells and their transfectants bearing human integrin alpha(v)beta3 cDNA (alpha(v)beta3-CHO-K1 cells). The liver accumulation of alpha(v)beta3-CHO-K1 cells was significantly higher than that of CHO-K1 cells after injection via the portal vein, whereas no significant difference was observed in the lung accumulation after tail vein injection, suggesting a specific interaction of alpha(v)beta3-CHO-K1 cells with the hepatic sinusoids. Furthermore, to clarify the precise location of each cell in the liver, i.e., to determine whether individual cells were intravascularly localized or had extravasated, we performed intravital fluorescence microscopy (IVM) on the liver by using stable transfectants bearing the green fluorescent protein (GFP) gene, namely, GFP-CHO-K1 and GFP-alpha(v)beta3-CHO-K1 cells. Both types of cells remained in the hepatic blood vessels 1 h after injection via the portal vein. On the other hand, expression of integrin alpha(v)beta3 promoted the cells to reach the extravascular region after 24 h. These results suggest the possibility that the specific accumulation of alpha(v)beta3-CHO-K1 cells in the liver is followed by migration of the cells into the extravascular region. Interestingly, the adhesion of the two types of cells to hepatic sinusoidal endothelial cells in vitro did not correspond to in vivo accumulation of these cells. Therefore, integrin alpha(v)beta3 may function to promote extravasation of integrin alpha(v)beta3-expressing tumor cells in liver through a process possibly mediated by vitronectin produced by this organ.
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