ArticleProceedings of the National Academy of Sciences of the United States of America2003
Reciprocal chromosome painting among human, aardvark, and elephant (superorder Afrotheria) reveals the likely eutherian ancestral karyotype.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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63 citing papers in PubMed, 175 citations in OpenAlex.
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- Chromosome-level genome assembly of the common tenrec, Tenrec ecaudatus (Schreber, 1778), a new model for early placental mammal evolution.BMC genomics · 2026Article
- Three-dimensional genome architecture persists in a 52,000-year-old woolly mammoth skin sample.Cell · 2024Article
- Haplotype-resolved chromosome-scale genomes of the Asian and African Savannah Elephants.Scientific data · 2024Article
- Establishment of Primary Adult Skin Fibroblast Cell Lines from African Savanna Elephants (Animals : an open access journal from MDPI · 2023Article
- Supernumerary Marker Chromosome Identified in Asian Elephant (Animals : an open access journal from MDPI · 2023Article
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- Evidence that DNA repair genes, a family of tumor suppressor genes, are associated with evolution rate and size of genomes.Human genomics · 2019Article
- Karyotype, evolution and phylogenetic reconstruction in Micronycterinae bats with implications for the ancestral karyotype of Phyllostomidae.BMC evolutionary biology · 2019Article
- Marsupial chromosome DNA content and genome size assessed from flow karyotypes: invariable low autosomal GC content.Royal Society open science · 2018Article
- A Postgenomic Perspective on Molecular Cytogenetics.Current genomics · 2018Article
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- Chromosomal evolution among leaf-nosed nectarivorous bats--evidence from cross-species chromosome painting (Phyllostomidae, Chiroptera).BMC evolutionary biology · 2013Article
- Chromosome painting in three-toed sloths: a cytogenetic signature and ancestral karyotype for Xenarthra.BMC evolutionary biology · 2012Article
- Review
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- Chromosomal rearrangements and karyotype evolution in carnivores revealed by chromosome painting.Heredity · 2012Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
Abstract
The Afrotheria, a supraordinal grouping of mammals whose radiation is rooted in Africa, is strongly supported by DNA sequence data but not by their disparate anatomical features. We have used flow-sorted human, aardvark, and African elephant chromosome painting probes and applied reciprocal painting schemes to representatives of two of the Afrotherian orders, the Tubulidentata (aardvark) and Proboscidea (elephants), in an attempt to shed additional light on the evolutionary affinities of this enigmatic group of mammals. Although we have not yet found any unique cytogenetic signatures that support the monophyly of the Afrotheria, embedded within the aardvark genome we find the strongest evidence yet of a mammalian ancestral karyotype comprising 2n = 44. This karyotype includes nine chromosomes that show complete conserved synteny to those of man, six that show conservation as single chromosome arms or blocks in the human karyotype but that occur on two different chromosomes in the ancestor, and seven neighbor-joining combinations (i.e., the synteny is maintained in the majority of species of the orders studied so far, but which corresponds to two chromosomes in humans). The comparative chromosome maps presented between human and these Afrotherian species provide further insight into mammalian genome organization and comparative genomic data for the Afrotheria, one of the four major evolutionary clades postulated for the Eutheria.
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