ArticleJournal of virology2003
Kinetics of virus-specific CD8+ -T-cell expansion and trafficking following central nervous system infection.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 92 citations in OpenAlex.
- bTInternational journal of molecular sciences · 2025Article
- Sustained Infiltration of Neutrophils Into the CNS Results in Increased Demyelination in a Viral-Induced Model of Multiple Sclerosis.Frontiers in immunology · 2022Article
- Evaluating the role of chemokines and chemokine receptors involved in coronavirus infection.Expert review of clinical immunology · 2022Article
- Murine-β-coronavirus-induced neuropathogenesis sheds light on CNS pathobiology of SARS-CoV2.Journal of neurovirology · 2021Review
- Programmed death ligand-1 induction restrains the cytotoxic T lymphocyte response against microglia.Glia · 2021Article
- Dysregulated Microglial Cell Activation and Proliferation Following Repeated Antigen Stimulation.Frontiers in cellular neuroscience · 2021Article
- mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2.PLoS pathogens · 2020Article
- Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry.Journal of visualized experiments : JoVE · 2020Article
- Antiallodynic Effects of Cannabinoid Receptor 2 (CBPain research & management · 2019Article
- Reactive glia promote development of CD103Immunity, inflammation and disease · 2018Article
- Nitrosative damage during retrovirus infection-induced neuropathic pain.Journal of neuroinflammation · 2018Article
- Protective Humoral Immunity in the Central Nervous System Requires Peripheral CD19-Dependent Germinal Center Formation following Coronavirus Encephalomyelitis.Journal of virology · 2017Article
- A Neuroprimer: Principles of Central Nervous System Immunity.Seminars in pediatric neurology · 2017Article
- The PD-1: PD-L1 pathway promotes development of brain-resident memory T cells following acute viral encephalitis.Journal of neuroinflammation · 2017Article
- T cell responses in the central nervous system.Nature reviews. Immunology · 2017Review
- Modulation of Microglial Cell Fcγ Receptor Expression Following Viral Brain Infection.Scientific reports · 2017Article
- Glycolysis determines dichotomous regulation of T cell subsets in hypoxia.The Journal of clinical investigation · 2016Article
- Glial cell activation, recruitment, and survival of B-lineage cells following MCMV brain infection.Journal of neuroinflammation · 2016Article
- Self-reactive CD4(+) T cells activated during viral-induced demyelination do not prevent clinical recovery.Journal of neuroinflammation · 2015Article
- Chronic reactive gliosis following regulatory T cell depletion during acute MCMV encephalitis.Glia · 2015Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
CD8+ T cells control acute infection of the central nervous system (CNS) by neurotropic mouse hepatitis virus but do not suffice to achieve sterile immunity. To determine the lag between T-cell priming and optimal activity within the CNS, the accumulation of virus-specific CD8+ T cells in the CNS relative to that in peripheral lymphoid organs was assessed by using gamma interferon-specific ELISPOT assays and class I tetramer staining. Virus-specific CD8+ T cells were first detected in the cervical lymph nodes. Expansion in the spleen was delayed and less pronounced but also preceded accumulation in the CNS. The data further suggest peripheral acquisition of cytolytic function, thus enhancing CD8+ -T-cell effector function upon cognate antigen recognition in the CNS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.