ArticleJournal of virology2003
The interaction between the major capsid protein and the smallest capsid protein of human cytomegalovirus is dependent on two linear sequences in the smallest capsid protein.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Review
- Membraneless Compartmentalization of Nuclear Assembly Sites during Murine Cytomegalovirus Infection.Viruses · 2023Article
- Article
- Localization of the WD repeat-containing protein 5 to the Virion Assembly Compartment Facilitates Human Cytomegalovirus Assembly.Journal of virology · 2021Article
- Temporal dynamics of protein complex formation and dissociation during human cytomegalovirus infection.Nature communications · 2020Article
- Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97.Viruses · 2018Article
- Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150.Science (New York, N.Y.) · 2017Article
- Article
- The Essential Human Cytomegalovirus Proteins pUL77 and pUL93 Are Structural Components Necessary for Viral Genome Encapsidation.Journal of virology · 2016Article
- A hydrophobic domain within the small capsid protein of Kaposi's sarcoma-associated herpesvirus is required for assembly.The Journal of general virology · 2014Article
- Article
- Yeast two hybrid analyses reveal novel binary interactions between human cytomegalovirus-encoded virion proteins.PloS one · 2011Article
- Identification of binary interactions between human cytomegalovirus virion proteins.Journal of virology · 2011Article
- Functions of Varicella-zoster virus ORF23 capsid protein in viral replication and the pathogenesis of skin infection.Journal of virology · 2008Article
- Interaction of the putative human cytomegalovirus portal protein pUL104 with the large terminase subunit pUL56 and its inhibition by benzimidazole-D-ribonucleosides.Journal of virology · 2005Article
- Human cytomegalovirus UL130 protein promotes endothelial cell infection through a producer cell modification of the virion.Journal of virology · 2005Article
- Three-dimensional localization of the smallest capsid protein in the human cytomegalovirus capsid.Journal of virology · 2005Article
- Comprehensive mutational analysis of a herpesvirus gene in the viral genome context reveals a region essential for virus replication.Journal of virology · 2004Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The assembly of human cytomegalovirus (HCMV) with recombinant systems has not been accomplished. An understanding of specific interactions between individual capsid proteins could point to unique characteristics of the assembly process of HCMV capsids. Similar to its herpes simplex virus counterpart, VP26 (UL35), the HCMV smallest capsid protein (SCP; UL48/49) decorates hexons in the mature capsid. In contrast to VP26, the HCMV SCP is essential for virus assembly. In this study we have shown that the major capsid protein (MCP) and the SCP interact in the cytoplasm of transfected cells and can be coprecipitated from insect cells expressing the MCP and the SCP. Using a two-hybrid reporter assay, we demonstrated that two linear sequences within the SCP are sufficient for SCP and MCP interactions.
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Registered trials
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