ReviewMolecular diversity2002
Exploring privileged structures: the combinatorial synthesis of cyclic peptides.
Review in Molecular diversity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
26 citing papers in PubMed.
- Strategies for converting turn-motif and cyclic peptides to small molecules for targeting protein-protein interactions.RSC chemical biology · 2024Review
- Effects of Conformational Constraint on Peptide Solubility Limits.The journal of physical chemistry. B · 2022Article
- Article
- Development of peptides targeting receptor binding site of the envelope glycoprotein to contain the West Nile virus infection.Scientific reports · 2021Article
- Approaches for peptide and protein cyclisation.Organic & biomolecular chemistry · 2021Review
- Methodologies for Backbone Macrocyclic Peptide Synthesis Compatible With Screening Technologies.Frontiers in chemistry · 2020Review
- NMR-based investigations of acyl-functionalized piperazines concerning their conformational behavior in solution.RSC advances · 2018Article
- Development of a Novel Backbone Cyclic Peptide Inhibitor of the Innate Immune TLR/IL1R Signaling Protein MyD88.Scientific reports · 2018Article
- Intein-mediated backbone cyclization of entolimod confers enhanced radioprotective activity in mouse models.PeerJ · 2018Article
- Exploitation of the Ornithine Effect Enhances Characterization of Stapled and Cyclic Peptides.Journal of the American Society for Mass Spectrometry · 2016Article
- High-Throughput Screening by Nuclear Magnetic Resonance (HTS by NMR) for the Identification of PPIs Antagonists.Current topics in medicinal chemistry · 2015Review
- Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121: insights from biochemical studies and crystal structures.The Journal of biological chemistry · 2013Article
- An amino acid substitution inhibits specialist herbivore production of an antagonist effector and recovers insect-induced plant defenses.Plant physiology · 2012Article
- Diastereoselective synthesis of diketopiperazine bis-α,β-epoxides.The Journal of organic chemistry · 2011Article
- Defining scaffold geometries for interacting with proteins: geometrical classification of secondary structure linking regions.Journal of computer-aided molecular design · 2010Article
- Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors.Current pharmaceutical design · 2010Review
- Conformationally homogeneous heterocyclic pseudotetrapeptides as three-dimensional scaffolds for rational drug design: receptor-selective somatostatin analogues.Angewandte Chemie (International ed. in English) · 2009Article
- Synthesis and in vitro antiproliferative activity against human cancer cell lines of novel 5-(4-methyl-benzylidene)-thiazolidine-2,4-diones.Investigational new drugs · 2008Article
- Solid-phase and microwave-assisted syntheses of 2,5-diketopiperazines: small molecules with great potential.Combinatorial chemistry & high throughput screening · 2007Review
- Synthesis and antiviral activities of new acyclic and "double-headed" nucleoside analogues.Bioorganic chemistry · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Head-to-tail cyclic peptides have been reported to bind to multiple, unrelated classes of receptor with high affinity. They may therefore be considered to be privileged structures. This review outlines the strategies by which both macrocyclic cyclic peptides and cyclic dipeptides or diketopiperazines have been synthesised in combinatorial libraries. It also briefly outlines some of the biological applications of these molecules, thereby justifying their inclusion as privileged structures.
Indexed as
Identifiers
12549678What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.