ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2003
The neuronal targets for GABAergic reticulospinal inhibition that stops swimming in hatchling frog tadpoles.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- From decision to action: Detailed modelling of frog tadpoles reveals neuronal mechanisms of decision-making and reproduces unpredictable swimming movements in response to sensory signals.PLoS computational biology · 2021Article
- Growth at Cold Temperature Increases the Number of Motor Neurons to Optimize Locomotor Function.Current biology : CB · 2019Article
- Nervous mechanisms of locomotion in different directions.Current opinion in physiology · 2019Article
- Distribution and neuronal circuit of spexin 1/2 neurons in the zebrafish CNS.Scientific reports · 2019Article
- Integration of Descending Command Systems for the Generation of Context-Specific Locomotor Behaviors.Frontiers in neuroscience · 2017Review
- Activity in descending dopaminergic neurons represents but is not required for leg movements in the fruit fly Drosophila.Physiological reports · 2015Article
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- Behavioral observation of Xenopus tadpole swimming for neuroscience labs.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2014Article
- How neurons generate behavior in a hatchling amphibian tadpole: an outline.Frontiers in behavioral neuroscience · 2010Article
- Roles for inhibition: studies on networks controlling swimming in young frog tadpoles.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2008Review
- Metamodulation of a spinal locomotor network by nitric oxide.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Mechanosensory activation of a motor circuit by coactivation of two projection neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Brainstem control of activity and responsiveness in resting frog tadpoles: tonic inhibition.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2004Article
- Spinal and supraspinal functions of noradrenaline in the frog embryo: consequences for motor behaviour.The Journal of physiology · 2003Article
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Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In most animals locomotion can be started and stopped by specific sensory cues. We are using a simple vertebrate, the hatchling Xenopus tadpole, to study a neuronal pathway that turns off locomotion. In the tadpole, swimming stops when the head contacts solid objects or the water's surface meniscus. The primary sensory neurons are in the trigeminal ganglion and directly excite inhibitory reticulospinal neurons in the hindbrain. These project axons into the spinal cord and release GABA to inhibit spinal neurons and stop swimming. We ask whether there is specificity in the types of spinal neuron inhibited. We used single-neuron recording to determine which classes of spinal neurons receive inhibition when the head skin is pressed. Ventral motoneurons and premotor interneurons involved in generating the swimming rhythm receive reliable GABAergic inhibition. More dorsal inhibitory premotor interneurons are inhibited less reliably and some are excited. Dorsal sensory pathway interneurons that start swimming following a touch to the trunk skin do not appear to receive such inhibition. There is therefore specificity in the formation of descending inhibitory connections so that more ventral neurons producing swimming are most strongly inhibited.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.