ArticleHistochemistry and cell biology2003
Upregulation of TrkA neurotrophin receptor expression in the thymic subcapsular, paraseptal, perivascular, and cortical epithelial cells during thymus regeneration.
Article in Histochemistry and cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 29 citations in OpenAlex.
- Descriptive and functional characterization of epidermal growth factor‑like domain 8 in mouse cortical thymic epithelial cells by integrated analysis of gene expression signatures and networks.International journal of molecular medicine · 2021Article
- Characterization of the expression of cytokeratins 5, 8, and 14 in mouse thymic epithelial cells during thymus regeneration following acute thymic involution.Anatomy & cell biology · 2011Article
- Expression of 4-1BB and 4-1BBL in thymocytes during thymus regeneration.Experimental & molecular medicine · 2009Article
- RANKL stimulates proliferation, adhesion and IL-7 expression of thymic epithelial cells.Experimental & molecular medicine · 2008Article
- Nerve growth factor immunoreactivity of mast cells in acute involuted human thymus.Inflammation · 2007Article
- Thymocyte depletion affects neurotrophin receptor expression in thymic stromal cells.Journal of anatomy · 2006Article
- Upregulation of receptor activator of nuclear factor-kappaB ligand expression in the thymic subcapsular, paraseptal, perivascular, and medullary epithelial cells during thymus regeneration.Histochemistry and cell biology · 2005Article
- Innovative techniques and applications in histochemistry and cell biology.Histochemistry and cell biology · 2003Review
- Neurotrophins and the immune system.Journal of anatomy · 2003Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroimmune networks in the thymic microenvironment are thought to be involved in the regulation of T cell development. Here, we report upon an examination of the expression of the TrkA neurotrophin receptor, the high affinity receptor for nerve growth factor, during regeneration following acute involution induced by cyclophosphamide in the rat thymus. Light and electron microscopic immunocytochemistry demonstrated enhanced expression of the TrkA receptor in the subcapsular, paraseptal, perivascular, and cortical epithelial cells during thymus regeneration. In addition, various morphological alterations, suggestive of a hyperfunctional and dynamic state, of the subcapsular, paraseptal, and perivascular epithelial cells were also observed. The presence of TrkA protein in extracts from the control and regenerating rat thymus was confirmed by western blot. Furthermore, RT-PCR analysis supported these results by demonstrating that thymic extracts contain TrkA mRNA at higher levels during thymus regeneration. Thus, our results suggest that the TrkA receptor located on the thymic subcapsular, paraseptal, perivascular, and cortical epithelial cells could play a role in the development of new T cells to replace T cells damaged during thymus regeneration.
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