ArticleEuropean journal of clinical nutrition2003
Long-chain polyunsaturated fatty acids at birth and cognitive function at 7 y of age.
Article in European journal of clinical nutrition, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- A Meta-Analysis of Stressors from the Total Environment Associated with Children's General Cognitive Ability.International journal of environmental research and public health · 2020Pooled it
- Contributions of a Child's Built, Natural, and Social Environments to Their General Cognitive Ability: A Systematic Scoping Review.PloS one · 2016Pooled it
- The Kansas University DHA Outcomes Study (KUDOS) clinical trial: long-term behavioral follow-up of the effects of prenatal DHA supplementation.The American journal of clinical nutrition · 2019Trial
- Association between Blood Omega-3 Index and Cognition in Typically Developing Dutch Adolescents.Nutrients · 2016Trial
- Omega-3 supplementation during the first 5 years of life and later academic performance: a randomised controlled trial.European journal of clinical nutrition · 2015Trial
- International Society of Sports Nutrition Position Stand: Long-Chain Omega-3 Polyunsaturated Fatty Acids.Journal of the International Society of Sports Nutrition · 2025Review
- Patterns of perinatal polyunsaturated fatty acid status and associated dietary or candidate-genetic factors.Journal of lipid research · 2024Article
- New Perspectives on the Associations between Blood Fatty Acids, Growth Parameters, and Cognitive Development in Global Child Populations.Nutrients · 2023Review
- Prospects for improving future mental health of children through prenatal maternal micronutrient supplementation in China.Pediatric investigation · 2020Review
- Vegetarian Diet during Pregnancy Is Not Associated with Poorer Cognitive Performance in Children at Age 6-7 Years.Nutrients · 2019Observational
- Protective effects of omega-3 fatty acids against Alzheimer's disease in rat brain endothelial cells.Brain and behavior · 2018Article
- Arachidonic acid and DHA status in pregnant women is not associated with cognitive performance of their children at 4 or 6-7 years.The British journal of nutrition · 2018Article
- Executive functions and the ω-6-to-ω-3 fatty acid ratio: a cross-sectional study.The American journal of clinical nutrition · 2017Article
- Detection and treatment of omega-3 fatty acid deficiency in psychiatric practice: Rationale and implementation.Lipids in health and disease · 2016Review
- Role of perinatal long-chain omega-3 fatty acids in cortical circuit maturation: Mechanisms and implications for psychopathology.World journal of psychiatry · 2015Review
- Docosahexaenoic acid status at 9 months is inversely associated with communicative skills in 3-year-old girls.Maternal & child nutrition · 2013Article
- Breast feeding and intergenerational social mobility: what are the mechanisms?Archives of disease in childhood · 2013Article
- The relationship of docosahexaenoic acid (DHA) with learning and behavior in healthy children: a review.Nutrients · 2013Review
- Automated high-throughput fatty acid analysis of umbilical cord serum and application to an epidemiological study.Lipids · 2012Article
- Maternal serum docosahexaenoic acid and schizophrenia spectrum disorders in adult offspring.Schizophrenia research · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDuring the central nervous system (CNS) growth spurt, rapid accretion of long chain polyunsaturated fatty acids (LCPUFA) takes place. This particularly concerns docosahexaenoic acid (DHA, 22:6n-3) and arachidonic acid (AA, 20:4n-6), which are thought to play important roles in CNS development and function. The aim of this study was to investigate the relationship between cognitive performance at 7 y of age and LCPUFA levels in umbilical venous plasma phospholipids, representing the prenatal fatty acid availability, and in plasma phospholipids sampled at 7 y.
designAs part of a follow-up study, the cognitive performance of 306 children, born at term, was assessed at 7 y of age with the Kaufman Assessment Battery for Children. Backward stepwise regression analysis was used to study the relationship between the outcomes and LCPUFA status. Social class, maternal intelligence and parenting skills were included as covariables, among others.
resultsResults show no significant association with either DHA or AA at birth and the cognitive performance at 7 y of age. The LCPUFA levels at 7 y were not associated with these outcomes either. Consistent with the literature, significant relationships were found between cognitive outcome measures and maternal education, maternal intelligence and the child's birthweight.
conclusionsIn conclusion, our results do not provide evidence for a positive association between cognitive performance at 7 y and LCPUFA status at birth or at 7 y of age.
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