ArticleProceedings of the National Academy of Sciences of the United States of America2003
Quantitative imaging of the T cell antitumor response by positron-emission tomography.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed.
- Human cancer-targeted immunity via transgenic hematopoietic stem cell progeny.Nature communications · 2025Article
- Application of magnetic nanoparticles in adoptive cell therapy of cancer; training, guiding and imaging cells.Nanomedicine (London, England) · 2024Review
- SITC cancer immunotherapy resource document: a compass in the land of biomarker discovery.Journal for immunotherapy of cancer · 2020Article
- Article
- Clinical Tracking of Cell Transfer and Cell Transplantation: Trials and Tribulations.Radiology · 2018Review
- Imaging T Cell Dynamics and Function Using PET and Human Nuclear Reporter Genes.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Review
- Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography.Nature communications · 2017Article
- Advancing Immune and Cell-Based Therapies Through Imaging.Molecular imaging and biology · 2017Review
- Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma.Science translational medicine · 2017Article
- In vivo monitoring of transfected DNA, gene expression kinetics, and cellular immune responses in mice immunized with a human NIS gene-expressing plasmid.International journal of immunopathology and pharmacology · 2016Article
- Imaging of Sleeping Beauty-Modified CD19-Specific T Cells Expressing HSV1-Thymidine Kinase by Positron Emission Tomography.Molecular imaging and biology · 2016Article
- Imaging Biomarkers in Immunotherapy.Biomarkers in cancer · 2016Review
- Advances in PET Detection of the Antitumor T Cell Response.Advances in immunology · 2016Review
- Comparative Analysis of T Cell Imaging with Human Nuclear Reporter Genes.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2015Article
- Imaging aspects of the tumor stroma with therapeutic implications.Pharmacology & therapeutics · 2014Review
- Near-infrared imaging of adoptive immune cell therapy in breast cancer model using cell membrane labeling.PloS one · 2014Article
- Tracking immune cells in vivo using magnetic resonance imaging.Nature reviews. Immunology · 2013Review
- Rebuilding cancer metastasis in the mouse.Molecular oncology · 2013Review
- In vivo Noninvasive Small Animal Molecular Imaging.Osong public health and research perspectives · 2012Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
We describe a noninvasive, quantitative, and tomographic method to visualize lymphocytes within the whole animal. We used positron-emission tomography (PET) to follow the localization of adoptively transferred immune T lymphocytes. Splenic T cells from animals that had rejected a Moloney murine sarcoma virus/Moloney murine leukemia virus (M-MSV/M-MuLV)-induced tumor were marked with a PET reporter gene, injected into tumor-bearing mice, and imaged in a microPET by using a substrate specific for the reporter. Specific localization of immune T cells to the antigen-positive tumor was detected over time, by sequential imaging of the same animals. Naive T cells did not localize to the tumor site, indicating that preimmunization was required. Autoradiography and immunohistochemistry analysis corroborated the microPET data. The method we have developed can be used to assess the effects of immunomodulatory agents intended to potentiate the immune response to cancer, and can also be useful for the study of other cell-mediated immune responses, including autoimmunity.
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Registered trials
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