ArticleBiophysical journal2003
A prestressed cable network model of the adherent cell cytoskeleton.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 103 citations in OpenAlex.
- Subcellular mechano-regulation of cell migration in confined extracellular microenvironment.Biophysics reviews · 2023Review
- Study of the Effect of Cell Prestress on the Cell Membrane Penetration Behavior by Atomic Force Microscopy.Micromachines · 2023Article
- Altered mechanical properties of actin fibers due to breast cancer invasion: parameter identification based on micropipette aspiration and multiscale tensegrity modeling.Medical & biological engineering & computing · 2021Article
- Nanoscopic Approach to Study the Early Stages of Epithelial to Mesenchymal Transition (EMT) of Human Retinal Pigment Epithelial (RPE) Cells In Vitro.Life (Basel, Switzerland) · 2020Article
- An Active Biomechanical Model of Cell Adhesion Actuated by Intracellular Tensioning-Taxis.Biophysical journal · 2020Article
- Automatic directional analysis of cell fluorescence images and morphological modeling of microfilaments.Medical & biological engineering & computing · 2019Article
- Empirically Determined Vascular Smooth Muscle Cell Mechano-Adaptation Law.Journal of biomechanical engineering · 2017Article
- Modeling cell shape and dynamics on micropatterns.Cell adhesion & migration · 2016Article
- Deformability-based circulating tumor cell separation with conical-shaped microfilters: Concept, optimization, and design criteria.Biomicrofluidics · 2015Article
- In situ determination of alveolar septal strain, stress and effective Young's modulus: an experimental/computational approach.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Dynamics of cell shape and forces on micropatterned substrates predicted by a cellular Potts model.Biophysical journal · 2014Article
- Tensegrity, cellular biophysics, and the mechanics of living systems.Reports on progress in physics. Physical Society (Great Britain) · 2014Review
- Article
- Stress transmission within the cell.Comprehensive Physiology · 2011Review
- Complexity of the tensegrity structure for dynamic energy and force distribution of cytoskeleton during cell spreading.PloS one · 2010Article
- A mechanical model of actin stress fiber formation and substrate elasticity sensing in adherent cells.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Contribution of the cytoskeleton to the compressive properties and recovery behavior of single cells.Biophysical journal · 2009Article
- Mechanical and spatial determinants of cytoskeletal geodesic dome formation in cardiac fibroblasts.Integrative biology : quantitative biosciences from nano to macro · 2009Article
- Filamentous network mechanics and active contractility determine cell and tissue shape.Biophysical journal · 2008Article
- Propagation of mechanical stress through the actin cytoskeleton toward focal adhesions: model and experiment.Biophysical journal · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A prestressed cable network is used to model the deformability of the adherent cell actin cytoskeleton. The overall and microstructural model geometries and cable mechanical properties were assigned values based on observations from living cells and mechanical measurements on isolated actin filaments, respectively. The models were deformed to mimic cell poking (CP), magnetic twisting cytometry (MTC) and magnetic bead microrheometry (MBM) measurements on living adherent cells. The models qualitatively and quantitatively captured the fibroblast cell response to the deformation imposed by CP while exhibiting only some qualitative features of the cell response to MTC and MBM. The model for CP revealed that the tensed peripheral actin filaments provide the key resistance to indentation. The actin filament tension that provides mechanical integrity to the network was estimated at approximately 158 pN, and the nonlinear mechanical response during CP originates from filament kinematics. The MTC and MBM simulations revealed that the model is incomplete, however, these simulations show cable tension as a key determinant of the model response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.