ArticleBiophysical journal2003
Material studies of lipid vesicles in the L(alpha) and L(alpha)-gel coexistence regimes.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 49 citations in OpenAlex.
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- A Permeability Study of O2 and the Trace Amine p-Tyramine through Model Phosphatidylcholine Bilayers.PloS one · 2015Article
- Phase separation and fluctuations in mixtures of a saturated and an unsaturated phospholipid.Biophysical journal · 2012Article
- Imaging lipid lateral organization in membranes with C-laurdan in a confocal microscope.Journal of lipid research · 2012Article
- Influence of vitamin C on alcohol binding to phospholipid monolayers.European biophysics journal : EBJ · 2008Article
- Effects of the Bacillus thuringiensis toxin Cry1Ab on membrane currents of isolated cells of the ruminal epithelium.The Journal of membrane biology · 2007Article
- Coexisting stripe- and patch-shaped domains in giant unilamellar vesicles.Biochemistry · 2006Article
- Bolaamphiphiles promote phospholipid translocation across vesicle membranes.Journal of the American Chemical Society · 2006Article
- Galactosylceramide domain microstructure: impact of cholesterol and nucleation/growth conditions.Biophysical journal · 2006Article
- Elasticity and phase behavior of DPPC membrane modulated by cholesterol, ergosterol, and ethanol.Biophysical journal · 2005Article
- The influence of short-chain alcohols on interfacial tension, mechanical properties, area/molecule, and permeability of fluid lipid bilayers.Biophysical journal · 2004Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, we utilize micropipette aspiration and fluorescence imaging to examine the material properties of lipid vesicles made from mixtures of palmitoyloleoylphosphocholine (POPC) and dipalmitoylphosphatidylcholine (DPPC). At elevated temperatures/low DPPC fractions, these lipids are in a miscible liquid crystalline (L(alpha)) state, whereas at lower temperatures/higher DPPC fractions they phase-separate into L(alpha) and gel phases. We show that the elastic modulus, K, and critical tension, tau(c), of L(alpha) vesicles are independent of DPPC fraction. However, as the sample temperature is increased from 15 degrees C to 45 degrees C, we measure decreases in both K and tau(c) of 20% and 50%, respectively. The elasticity change is likely driven by a change in interfacial tension. We describe the reduction in critical tension using a simple model of thermally activated membrane pores. Vesicles with two-phase coexistence exhibit material properties that differ from L(alpha) vesicles including critical tensions that are 20-40% lower. Fluorescence imaging of phase coexistent POPC/DPPC vesicles shows that the DPPC-rich domains exist in an extended network structure that exhibits characteristics of a solid. This gel network explains many of the unusual material properties of two-phase membranes.
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