ArticleBiophysical journal2003
The link between ion permeation and inactivation gating of Kv4 potassium channels.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- KChIP1 splice variants modulate Kv4 channels by promoting P/C-type inactivation features.Scientific reports · 2026Article
- Dual mechanisms contribute to enhanced voltage dependence of an electric fish potassium channel.Biophysical journal · 2024Article
- Activation and closed-state inactivation mechanisms of the human voltage-gated KMolecular cell · 2022Article
- Pharmacology of A-Type KHandbook of experimental pharmacology · 2021Article
- Nonsensing residues in S3-S4 linker's C terminus affect the voltage sensor set point in KThe Journal of general physiology · 2018Article
- Stabilization of the conductive conformation of a voltage-gated K+ (Kv) channel: the lid mechanism.The Journal of biological chemistry · 2013Article
- Voltage sensor inactivation in potassium channels.Frontiers in pharmacology · 2012Article
- Mechanisms of closed-state inactivation in voltage-gated ion channels.The Journal of physiology · 2011Review
- Closed-state inactivation in Kv4.3 isoforms is differentially modulated by protein kinase C.American journal of physiology. Cell physiology · 2009Article
- Dynamic coupling of voltage sensor and gate involved in closed-state inactivation of kv4.2 channels.The Journal of general physiology · 2009Article
- Single-channel properties of I K,slow1 and I K,slow2 in mouse ventricular myocytes.Pflugers Archiv : European journal of physiology · 2008Article
- Ternary Kv4.2 channels recapitulate voltage-dependent inactivation kinetics of A-type K+ channels in cerebellar granule neurons.The Journal of physiology · 2008Article
- Role of N-terminal domain and accessory subunits in controlling deactivation-inactivation coupling of Kv4.2 channels.Biophysical journal · 2008Article
- Mechanism of the modulation of Kv4:KChIP-1 channels by external K+.Biophysical journal · 2008Article
- Voltage-dependent gating rearrangements in the intracellular T1-T1 interface of a K+ channel.The Journal of general physiology · 2006Article
- Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms.The Journal of physiology · 2005Review
- Time- and voltage-dependent components of Kv4.3 inactivation.Biophysical journal · 2005Article
- Functionally active t1-t1 interfaces revealed by the accessibility of intracellular thiolate groups in kv4 channels.The Journal of general physiology · 2005Article
- Activation properties of Kv4.3 channels: time, voltage and [K+]o dependence.The Journal of physiology · 2004Article
- N-type inactivation features of Kv4.2 channel gating.Biophysical journal · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Kv4 potassium channels undergo rapid inactivation but do not seem to exhibit the classical N-type and C-type mechanisms present in other Kv channels. We have previously hypothesized that Kv4 channels preferentially inactivate from the preopen closed state, which involves regions of the channel that contribute to the internal vestibule of the pore. To further test this hypothesis, we have examined the effects of permeant ions on gating of three Kv4 channels (Kv4.1, Kv4.2, and Kv4.3) expressed in Xenopus oocytes. Rb(+) is an excellent tool for this purpose because its prolonged residency time in the pore delays K(+) channel closing. The data showed that, only when Rb(+) carried the current, both channel closing and the development of macroscopic inactivation are slowed (1.5- to 4-fold, relative to the K(+) current). Furthermore, macroscopic Rb(+) currents were larger than K(+) currents (1.2- to 3-fold) as the result of a more stable open state, which increases the maximum open probability. These results demonstrate that pore occupancy can influence inactivation gating in a manner that depends on how channel closing impacts inactivation from the preopen closed state. By examining possible changes in ionic selectivity and the influence of elevating the external K(+) concentration, additional experiments did not support the presence of C-type inactivation in Kv4 channels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.