ArticleBiophysical journal2003
Long-range signal transmission in autocrine relays.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
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- Quantitative analyses of EGFR localization and trafficking dynamics in the follicular epithelium.Development (Cambridge, England) · 2020Article
- Spherical Caps in Cell Polarization.Biophysical journal · 2018Article
- Dynamics and control of the ERK signaling pathway: Sensitivity, bistability, and oscillations.PloS one · 2018Article
- Article
- Cryptochrome in sponges: a key molecule linking photoreception with phototransduction.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2013Article
- Oscillatory flow accelerates autocrine signaling due to nonlinear effect of convection on receptor-related actions.Biophysical journal · 2013Article
- Effects of convective transport on chemical signal propagation in epithelia.Biophysical journal · 2012Article
- Probing embryonic stem cell autocrine and paracrine signaling using microfluidics.Annual review of analytical chemistry (Palo Alto, Calif.) · 2012Review
- Quantitative understanding of cell signaling: the importance of membrane organization.Current opinion in biotechnology · 2010Review
- A mathematical model of intercellular signaling during epithelial wound healing.Journal of theoretical biology · 2010Article
- Beyond the wiring diagram: signalling through complex neuromodulator networks.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Compensated optimal grids for elliptic boundary-value problems.Journal of computational physics · 2008Article
- Time and length scales of autocrine signals in three dimensions.Biophysical journal · 2007Article
- Noise can play an organizing role for the recurrent dynamics in excitable media.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Spatial analysis of 3' phosphoinositide signaling in living fibroblasts: I. Uniform stimulation model and bounds on dimensionless groups.Biophysical journal · 2004Article
- Discrete models of autocrine cell communication in epithelial layers.Biophysical journal · 2003Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular signaling induced by peptide growth factors can stimulate secretion of these molecules into the extracellular medium. In autocrine and paracrine networks, this can establish a positive feedback loop between ligand binding and ligand release. When coupled to intercellular communication by autocrine ligands, this positive feedback can generate constant-speed traveling waves. To demonstrate that, we propose a mechanistic model of autocrine relay systems. The model is relevant to the physiology of epithelial layers and to a number of in vitro experimental formats. Using asymptotic and numerical tools, we find that traveling waves in autocrine relays exist and have a number of unusual properties, such as an optimal ligand binding strength necessary for the maximal speed of propagation. We compare our results to recent observations of autocrine and paracrine systems and discuss the steps toward experimental tests of our predictions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.