ArticleBiophysical journal2003
Regulation of protein mobility via thermal membrane undulations.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The Effect of Thermal Fluctuation on the Receptor-Mediated Adhesion of a Cell Membrane to an Elastic Substrate.Membranes · 2017Article
- Effect of wall-mediated hydrodynamic fluctuations on the kinetics of a Brownian nanoparticle.Proceedings. Mathematical, physical, and engineering sciences · 2016Article
- Membrane Compartmentalization Reducing the Mobility of Lipids and Proteins within a Model Plasma Membrane.The journal of physical chemistry. B · 2016Article
- Particle Simulation of Oxidation Induced Band 3 Clustering in Human Erythrocytes.PLoS computational biology · 2015Article
- Endocytic accessory factors and regulation of clathrin-mediated endocytosis.Cold Spring Harbor perspectives in biology · 2014Review
- Article
- Multiscale simulation of protein mediated membrane remodeling.Seminars in cell & developmental biology · 2010Review
- Biophysics of magnetic orientation: strengthening the interface between theory and experimental design.Journal of the Royal Society, Interface · 2010Article
- Correlated diffusion of membrane proteins and their effect on membrane viscosity.Biophysical journal · 2009Article
- Hybrid coarse-graining approach for lipid bilayers at large length and time scales.The journal of physical chemistry. B · 2009Article
- Diffusion in a fluid membrane with a flexible cortical cytoskeleton.Biophysical journal · 2009Article
- Role of gp120 trimerization on HIV binding elucidated with Brownian adhesive dynamics.Biophysical journal · 2008Article
- Fluctuations of the red blood cell membrane: relation to mechanical properties and lack of ATP dependence.Biophysical journal · 2008Article
- Membrane remodeling from N-BAR domain interactions: insights from multi-scale simulation.Biophysical journal · 2007Article
- Bending a membrane: how clathrin affects budding.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Implicit solvent simulation models for biomembranes.European biophysics journal : EBJ · 2006Review
- 'KMC-TDGL'-a coarse-grained methodology for simulating interfacial dynamics in complex fluids: application to protein-mediated membrane processes.Molecular physics · 2006Article
- Coupling field theory with continuum mechanics: a simulation of domain formation in giant unilamellar vesicles.Biophysical journal · 2005Article
- Coupling field theory with mesoscopic dynamical simulations of multicomponent lipid bilayers.Biophysical journal · 2004Article
- Mesoscopic lateral diffusion in lipid bilayers.Biophysical journal · 2004Article
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1 author.
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Abstract
The in-plane diffusivelike motion of membrane bound proteins on the surface of cells is considered. We suggest, on the basis of theoretical arguments and simulation, that thermally excited undulations of the lipid bilayer may serve as a mechanism for proteins to hop between adjacent regions on the cell surface separated by barriers composed of internal cellular structure (e.g., the cytoskeleton). We specifically investigate the mobility of band 3 dimer on the surface of red blood cells where the spectrin cytoskeletal meshwork defines a series of "corrals" on the cell surface known to hinder protein motion. Previous models of this system have postulated that the cytoskeleton must deform to allow passage of membrane bound proteins out of these corral regions and have ignored fluctuations of the bilayer. Our model provides a complementary mechanism and we posit that the mobility of real proteins in real cells is likely the result of several mechanisms acting in parallel.
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