ArticleThe American journal of pathology2003
CC chemokine receptor 8 in the central nervous system is associated with phagocytic macrophages.
Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains a homeostatic Th17 cell state.Immunity · 2026Article
- STAT4-dependent regulation of neuroinflammation in atherosclerosis.Physiological reports · 2026Article
- STAT4-dependent regulation of neuroinflammation in atherosclerosis.bioRxiv : the preprint server for biology · 2026Article
- Design, molecular characterization and therapeutic investigation of a novel CCR8 peptide antagonist that attenuates acute liver injury by inhibiting infiltration and activation of macrophages.Acta pharmaceutica Sinica. B · 2025Article
- Chemokines as therapeutic targets for multiple sclerosis: a spatial and chronological perspective.Frontiers in immunology · 2025Review
- Human Primary Astrocytes Differently Respond to Pro- and Anti-Inflammatory Stimuli.Biomedicines · 2022Article
- Dynamic Responses of Microglia in Animal Models of Multiple Sclerosis.Frontiers in cellular neuroscience · 2020Article
- Changes in Chemokines and Chemokine Receptors Expression in a Mouse Model of Alzheimer's Disease.International journal of biological sciences · 2019Article
- Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8.Journal of extracellular vesicles · 2018Article
- Role of chemokine C-C motif ligand-1 in acute and chronic pulmonary inflammations.SpringerPlus · 2016Article
- Thymic stromal lymphopoietin deficiency attenuates experimental autoimmune encephalomyelitis.Clinical and experimental immunology · 2015Article
- Systematic Review of the Neurobiological Relevance of Chemokines to Psychiatric Disorders.Frontiers in cellular neuroscience · 2015Review
- Analysis of chemokines and receptors expression profile in the myelin mutant taiep rat.Oxidative medicine and cellular longevity · 2015Article
- Quantitative GPCR and ion channel transcriptomics in primary alveolar macrophages and macrophage surrogates.BMC immunology · 2012Article
- G protein-coupled receptors as therapeutic targets for multiple sclerosis.Cell research · 2012Review
- CCR8 signaling influences Toll-like receptor 4 responses in human macrophages in inflammatory diseases.Clinical and vaccine immunology : CVI · 2011Article
- Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis.The Journal of experimental medicine · 2008Article
- A promising therapeutic approach for multiple sclerosis: recombinant T-cell receptor ligands modulate experimental autoimmune encephalomyelitis by reducing interleukin-17 production and inhibiting migration of encephalitogenic cells into the CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Inflammation in adult and neonatal stroke.Clinical neuroscience research · 2006Article
- Involvement of beta-chemokines in the development of inflammatory demyelination.Journal of neuroinflammation · 2005Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
Abstract
CC chemokine receptor 8 (CCR8) has been detected in vitro on type 2 helper and regulatory lymphocytes, which might exert beneficial functions in multiple sclerosis (MS) and on macrophages and microglia, possibly promoting tissue injury in MS lesions. To discriminate the relevant expression pattern in vivo, we defined the cell types that expressed CCR8 in MS lesions and determined the relationship of CCR8 expression and demyelinating activity. CCR8 was not expressed on T cells but was associated with phagocytic macrophages and activated microglia in MS lesions and directly correlated with demyelinating activity. To identify factors associated with CCR8 expression, the study was extended to other central nervous system (CNS) pathologies. CCR8 was consistently expressed on phagocytic macrophages and activated microglia in stroke and progressive multifocal leukoencephalopathy, but not expressed on microglia in pathologies that lacked phagocytic macrophages such as senile change of the Alzheimer's type. CCR8 was up-regulated by macrophage differentiation and activating stimuli in vitro. In summary CNS CCR8 expression was associated with phagocytic macrophages and activated microglial cells in human CNS diseases, suggesting that CCR8 may be a feasible target for therapeutic intervention in MS. CCR8 expression may also indicate a selective program of mononuclear phagocyte gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.