ArticleInflammation2002
Modulation of leukocyte recruitment and IL-8 expression by the membrane attack complex of complement (C5b-9) in a rabbit model of antigen-induced arthritis.
Article in Inflammation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Functional Loss of Terminal Complement Complex Protects Rabbits from Injury-Induced Osteoarthritis on Structural and Cellular Level.Biomolecules · 2023Article
- Therapeutic Efficacy of aFrontiers in microbiology · 2020Article
- Immunopathological Characterization of Muscle Biopsy Samples from Immune-Mediated Necrotizing Myopathy Patients.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Ischemia-reperfusion Injury in the Brain: Mechanisms and Potential Therapeutic Strategies.Biochemistry & pharmacology : open access · 2016Article
- Dissecting the complement pathway in hepatic injury and regeneration with a novel protective strategy.The Journal of experimental medicine · 2014Article
- Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Sub-lytic C5b-9 induces functional changes in retinal pigment epithelial cells consistent with age-related macular degeneration.Eye (London, England) · 2011Article
- Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in mice.Journal of neuroinflammation · 2010Article
- The outer membrane protein VhOmp of Vibrio harveyi: pore-forming properties in black lipid membranes.The Journal of membrane biology · 2009Article
- The membrane attack complex (C5b-9) in liver cold ischemia and reperfusion injury.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2008Article
- The complement system plays a critical role in the development of experimental autoimmune anterior uveitis.Investigative ophthalmology & visual science · 2006Article
- Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis.Arthritis research & therapy · 2006Article
- Suppression of complement activation by recombinant Crry inhibits experimental autoimmune anterior uveitis (EAAU).Molecular immunologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complement system is thought to be a major physiological mediator of injury in a number of diseases including rheumatoid arthritis (RA). The membrane attack complex (MAC) of complement has been detected in RA tissue, suggesting that the MAC may be relevant to the pathogenesis of the disease. Deposition of sublytic concentrations of the MAC has been shown to promote the expression of proinflammatory mediators. In the present study, we utilized rabbits deficient in the complement protein C6 to elucidate the role of the MAC in mediating the pathogenesis of antigen-induced arthritis. Swelling, leukocyte accumulation, IL-8 expression, proteoglycan, and hydroxyproline content were assessed. Analysis of synovial tissue demonstrated a significant decrease in leukocyte influx and a parallel decrease in tissue associated IL-8 in joints of C6-deficient animals as compared to C6-sufficient animals. However, this did not correlate with the preservation of connective tissue. The results derived from this study provide evidence that the MAC has an important function in mediating leukocyte recruitment in antigen-induced arthritis but does not play a direct role in connective tissue breakdown.
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