ArticleThe Biochemical journal2003
Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro.
Article in The Biochemical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 48 citations in OpenAlex.
- Article
- B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals.Toxicology · 2017Article
- Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1'-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism.Toxicology letters · 2016Article
- Pancreatic progenitor-derived hepatocytes are viable and functional in a 3D high density bioreactor culture system.Toxicology research · 2016Article
- Pancreatic B-13 Cell Trans-Differentiation to Hepatocytes Is Dependent on Epigenetic-Regulated Changes in Gene Expression.PloS one · 2016Article
- Identification of miRNAs Involved in Reprogramming Acinar Cells into Insulin Producing Cells.PloS one · 2015Article
- Role of liver stem cells in hepatocarcinogenesis.World journal of stem cells · 2014Review
- Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studies.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Ontogenesis of hepatic and pancreatic stem cells.Stem cell reviews and reports · 2012Review
- Serine/threonine protein kinase SGK1 in glucocorticoid-dependent transdifferentiation of pancreatic acinar cells to hepatocytes.Journal of cell science · 2011Article
- Disrupted pancreatic exocrine differentiation and malabsorption in response to chronic elevated systemic glucocorticoid.The American journal of pathology · 2010Article
- Stem cells in the adult pancreas and liver.The Biochemical journal · 2007Review
- Hepatocyte-like cells transdifferentiated from a pancreatic origin can support replication of hepatitis B virus.Journal of virology · 2005Article
- Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.The Biochemical journal · 2005Article
- Hepatocyte progenitors in man and in rodents--multiple pathways, multiple candidates.International journal of experimental pathology · 2005Review
- Transdifferentiation, metaplasia and tissue regeneration.Organogenesis · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proliferating AR42J-B13 pancreatic cell line is known to respond to glucocorticoid treatment by producing foci of cells that express the liver-specific albumin gene. We demonstrate that this cell line also expresses liver-specific or liver-enriched functional cytochrome P450 proteins when stimulated to trans-differentiate into hepatocytes by glucocorticoid. These data suggest that this cell line has an unusual ability to trans-differentiate into functional hepatocytes and that it could be possible to generate a limitless supply of functional hepatocyte-like cells in vitro.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.