ArticleProceedings of the National Academy of Sciences of the United States of America2003
PPARdelta is a very low-density lipoprotein sensor in macrophages.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed, 299 citations in OpenAlex.
- Dietary lipids induce PPARd and BCL6 to repress macrophage IL-23 induction after intestinal injury and LPS exposure.Scientific reports · 2025Article
- PPARs in atherosclerosis: The spatial and temporal features from mechanism to druggable targets.Journal of advanced research · 2025Review
- Effects of Dietary Waste Wet Dates (Aquaculture nutrition · 2025Article
- The Role of PPARs in Breast Cancer.Cells · 2022Review
- CD1d-dependent rewiring of lipid metabolism in macrophages regulates innate immune responses.Nature communications · 2022Article
- Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages.Nature communications · 2021Article
- Diet-induced dyslipidemia induces metabolic and migratory adaptations in regulatory T cells.Cardiovascular research · 2021Article
- Regulation of lipid metabolism by the unfolded protein response.Journal of cellular and molecular medicine · 2021Review
- Transcriptional Regulation of Metabolic Pathways via Lipid-Sensing Nuclear Receptors PPARs, FXR, and LXR in NASH.Cellular and molecular gastroenterology and hepatology · 2021Review
- PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice.International journal of molecular sciences · 2020Review
- Macrophage ontogeny in the control of adipose tissue biology.Current opinion in immunology · 2020Review
- The Puzzling Conservation and Diversification of Lipid Droplets from Bacteria to Eukaryotes.Results and problems in cell differentiation · 2020Article
- Role of LpL (Lipoprotein Lipase) in Macrophage Polarization In Vitro and In Vivo.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2.Liver research (Beijing, China) · 2018Article
- Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease.Molecular metabolism · 2018Article
- Hydrogen sulfide mediates athero-protection against oxidative stress via S-sulfhydration.PloS one · 2018Article
- Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- CD36 actions in the heart: Lipids, calcium, inflammation, repair and more?Biochimica et biophysica acta · 2016Review
- Activation of PPAR-δ induces microRNA-100 and decreases the uptake of very low-density lipoprotein in endothelial cells.British journal of pharmacology · 2015Article
- Increasing adipocyte lipoprotein lipase improves glucose metabolism in high fat diet-induced obesity.The Journal of biological chemistry · 2015Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although triglyceride-rich particles, such as very low-density lipoprotein (VLDL), contribute significantly to human atherogenesis, the molecular basis for lipoprotein-driven pathogenicity is poorly understood. We demonstrate that in macrophages, VLDL functions as a transcriptional regulator via the activation of the nuclear receptor peroxisome proliferator-activated receptor delta. The signaling components of native VLDL are its triglycerides, whose activity is enhanced by lipoprotein lipase. Generation of peroxisome proliferator-activated receptor delta null macrophages verifies the absolute requirement of this transcription factor in mediating the VLDL response. Thus, our data reveal a pathway through which dietary triglycerides and VLDL can directly regulate gene expression in atherosclerotic lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.