ArticleInfection and immunity2003
Does host complement kill Borrelia burgdorferi within ticks?
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- OspA antibodies inhibit theInfection and immunity · 2026Article
- Monovalent and multivalent OspA mRNA-LNP vaccines elicit functional antibodies and protect against Borrelia burgdorferi in mice.NPJ vaccines · 2026Article
- An Fc-silent OspA monoclonal antibody passively protects mice from tick and intradermal Borrelia burgdorferi challenge.PloS one · 2026Article
- A Lyme disease mRNA vaccine targetingMolecular therapy. Nucleic acids · 2025Article
- Hitchhiker's Guide toJournal of bacteriology · 2024Review
- Single-domain antibodies reveal unique borrelicidal epitopes on the Lyme disease vaccine antigen, outer surface protein A (OspA).Infection and immunity · 2024Article
- Deployment of a Reservoir-Targeted Vaccine Against Borrelia burgdorferi Reduces the Prevalence of Babesia microti Coinfection in Ixodes scapularis Ticks.The Journal of infectious diseases · 2023Article
- Vector microbiota manipulation by host antibodies: the forgotten strategy to develop transmission-blocking vaccines.Parasites & vectors · 2022Review
- The Symbiotic Continuum Within Ticks: Opportunities for Disease Control.Frontiers in microbiology · 2022Review
- Anti-Microbiota Vaccine Reduces Avian Malaria Infection Within Mosquito Vectors.Frontiers in immunology · 2022Article
- Antigen-specific antibody and polyfunctional T cells generated by respiratory immunization with protective Burkholderia ΔtonB Δhcp1 live attenuated vaccines.NPJ vaccines · 2021Article
- Anti-Microbiota Vaccines Modulate the Tick Microbiome in a Taxon-Specific Manner.Frontiers in immunology · 2021Article
- Anti-Tick Microbiota Vaccine ImpactsVaccines · 2020Article
- New Insights Into CRASP-Mediated Complement Evasion in the Lyme Disease Enzootic Cycle.Frontiers in cellular and infection microbiology · 2020Review
- Polymorphic factor H-binding activity of CspA protects Lyme borreliae from the host complement in feeding ticks to facilitate tick-to-host transmission.PLoS pathogens · 2018Article
- Article
- The role of salivary and intestinal complement system inhibitors in the midgut protection of triatomines and mosquitoes.PloS one · 2009Article
- Borrelia burgdorferi complement regulator-acquiring surface proteins (BbCRASPs): Expression patterns during the mammal-tick infection cycle.International journal of medical microbiology : IJMM · 2008Review
- Evolving models of Lyme disease spirochete gene regulation.Wiener klinische Wochenschrift · 2006Review
- Borrelia burgdorferi regulates expression of complement regulator-acquiring surface protein 1 during the mammal-tick infection cycle.Infection and immunity · 2005Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The Lyme disease spirochete, Borrelia burgdorferi, inhabits the gut lumen of the tick vector. At this location the spirochete is exposed to host blood when a tick feeds. We report here on studies that were done with normal and complement-deficient (C3-knockout) mice to determine if the host complement system killed spirochetes within the vector. We found that spirochete numbers within feeding nymphs were not influenced by complement, most likely because host complement was inactivated within the vector. The Lyme disease outer surface protein A (OspA) vaccine is a transmission-blocking vaccine that targets spirochetes in the vector. In experiments with mice hyperimmunized with OspA, complement was not required to kill spirochetes within nymphs and to block transmission from nymphs to the vaccinated host. However, host complement did enhance the ability of OspA antibody to block larvae from acquiring spirochetes. Thus, the effects of OspA antibody on nymphal transmission and larval acquisition appear to be based on different mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.