ArticleInfection and immunity2003
Elevated immunoglobulin E against recombinant Brugia malayi gamma-glutamyl transpeptidase in patients with bancroftian filariasis: association with tropical pulmonary eosinophilia or putative immunity.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Parasitic lung diseases.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- The role of helminths in the development of non-communicable diseases.Frontiers in immunology · 2022Review
- The role of rare innate immune cells in Type 2 immune activation against parasitic helminths.Parasitology · 2017Review
- Allergic Sensitization Underlies Hyperreactive Antigen-Specific CD4+ T Cell Responses in Coincident Filarial Infection.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Particularities of allergy in the Tropics.The World Allergy Organization journal · 2016Review
- B1b cells recognize protective antigens after natural infection and vaccination.Frontiers in immunology · 2014Review
- Identification of B-cell epitopes in an antigen for inducing specific class of antibodies.Biology direct · 2013Article
- Tropical pulmonary eosinophilia--a review.The Indian journal of medical research · 2013Review
- Protective and pathological roles of mast cells and basophils.Nature reviews. Immunology · 2013Review
- Granulocytes in helminth infection -- who is calling the shots?Current medicinal chemistry · 2012Review
- Stage-specific proteomic expression patterns of the human filarial parasite Brugia malayi and its endosymbiont Wolbachia.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Cloning and expression of 21.1-kDa tegumental protein of Clonorchis sinensis and human antibody response to it as a trematode-nematode pan-specific serodiagnosis antigen.Parasitology research · 2011Article
- Induction of immunoglobulin G4 in human filariasis: an indicator of immunoregulation.Annals of tropical medicine and parasitology · 2010Review
- Brugia malayi excreted/secreted proteins at the host/parasite interface: stage- and gender-specific proteomic profiling.PLoS neglected tropical diseases · 2009Article
- Cardiac manifestations of parasitic infections part 1: overview and immunopathogenesis.Clinical cardiology · 2007Review
- Immunoglobulin E and eosinophil-dependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae.Infection and immunity · 2004Article
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Authors and funding
4 authors.
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Abstract
A major allergen of the lymphatic filarial nematode Brugia malayi, a homologue of gamma-glutamyl transpeptidase (gamma-GT), is involved in the pathology of tropical pulmonary eosinophilia (TPE) through its potent allergenicity and the induction of antibodies against the host pulmonary epithelium. To investigate the immunoglobulin G (IgG) subclass and IgE responses to recombinant B. malayi gamma-GT, we analyzed the results obtained from 51 patients with differing clinical manifestations of bancroftian filariasis. gamma-GT-specific IgG1, rather than IgG4, was the predominant IgG subclass, particularly in patients with TPE (geomean, 6,321 ng/ml; range, 78 to 354,867 ng/ml) and was 75 times higher than in patients with elephantiasis (CP) (P < 0.003) and 185 times higher than in endemic normal individuals (ENL) (P < 0.010). IgG2 responses were low and IgG3 was almost absent, with no significant differences among the groups. gamma-GT-specific IgG4 responses were significantly elevated in those with subclinical microfilaremia (MF) compared to the CP and ENL groups and correlated with the presence of circulating filarial antigen (CAg). More significantly, gamma-GT-specific IgE antibody levels were strikingly elevated in patients with TPE (geomean, 681 ng/ml; range, 61 to 23,841 ng/ml) and in the ENL group (geomean, 106 ng/ml; range, 13 to 1,405 ng/ml) whereas the gamma-GT-specific IgE level was 44 and 61 times lower in those with MF and CP, respectively (P < 0.001). Elevated gamma-GT-specific IgE/IgG4 ratios were demonstrated in patients with TPE (ratio, 45) and ENL (ratio, 107). Because expression of gamma-GT in Brugia infective third-stage larvae (L3) was demonstrated by immunoblot analysis, the elevated gamma-GT-specific IgE antibodies appear to be associated not only with pulmonary pathology but also with possible resistance to infection in lymphatic filariasis.
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