ArticleInfection and immunity2003
Oral treponemes and their outer membrane extracts activate human gingival epithelial cells through toll-like receptor 2.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- Nisin bacteriocin blocks T. denticola-triggered MMP2 activation and pathogen internalization via TLR2.Scientific reports · 2026Article
- Lacticaseibacillus paracasei KBL382 contributes to the immunomodulation in THP-1 cells.Journal of microbiology (Seoul, Korea) · 2026Article
- Treponema denticola major surface protein (Msp): a key player in periodontal pathogenicity and immune evasion.Archives of microbiology · 2025Review
- Clinical characteristics ofFrontiers in cellular and infection microbiology · 2025Article
- The Composition of Subgingival Microbiome in Hidradenitis Suppurativa and Periodontitis Patients.Pathogens (Basel, Switzerland) · 2023Article
- Stimulation of Human Periodontal Ligament Fibroblasts Using Purified Dentilisin Extracted fromBio-protocol · 2022Article
- Article
- Pathogenic Mechanisms ofFrontiers in oral health · 2022Review
- Paradigm shift in the pathogenesis and treatment of oral cancer and other cancers focused on the oralome and antimicrobial-based therapeutics.Periodontology 2000 · 2021Review
- Treponema denticola dentilisin triggered TLR2/MyD88 activation upregulates a tissue destructive program involving MMPs via Sp1 in human oral cells.PLoS pathogens · 2021Article
- Activation of the Innate Immune System by Treponema denticola Periplasmic Flagella through Toll-Like Receptor 2.Infection and immunity · 2018Article
- A Differential Innate Immune Response in Active and Chronic Stages of Bovine Infectious Digital Dermatitis.Frontiers in microbiology · 2018Article
- Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens.PloS one · 2016Article
- Inhibition of toll-like receptor 2 (TLR-2)-mediated response in human alveolar epithelial cells by mycolic acids and Mycobacterium tuberculosis mce1 operon mutant.Pathogens and disease · 2014Article
- Treponema denticola interactions with host proteins.Journal of oral microbiology · 2012Article
- Composition and localization of Treponema denticola outer membrane complexes.Infection and immunity · 2011Article
- Treponema denticola PrcB is required for expression and activity of the PrcA-PrtP (dentilisin) complex.Journal of bacteriology · 2010Article
- Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host.Periodontology 2000 · 2010Review
- Involvement of Toll-like receptors 2 and 4 in the innate immune response to Treponema denticola and its outer sheath components.Infection and immunity · 2009Article
- Treponema denticola does not induce production of common innate immune mediators from primary gingival epithelial cells.Oral microbiology and immunology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral treponemes are considered to be important in the development and progression of periodontal diseases. We investigated the mechanisms of recognition and activation of human gingival epithelial cells (HGEC) with the oral treponemes Treponema denticola, Treponema vincentii, and Treponema medium and their outer membrane extracts (OMEs). T. vincentii and T. medium but not T. denticola produced interleukin 8 (IL-8) in an HGEC culture. Further, all three treponemes induced IL-8 mRNA expression and NF-kappaB activation in HGEC. Among them, T. denticola especially exhibited trypsin- and chymotrypsin-like protease activities, and the addition of chymostatin, a chymotrypsin protease inhibitor, resulted in detectable IL-8 production by HGEC cultured with T. denticola. Additionally, IL-8 mRNA expression in HGEC cultured with the three treponemes and their OMEs was definitely inhibited by the mouse anti-human Toll-like receptor 2 (TLR2) monoclonal antibody TL2.1. These findings suggest that oral treponemes and their OMEs activate HGEC through TLR2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.