ArticleInfection and immunity2003
Toll-like receptor 4-positive macrophages protect mice from Pasteurella pneumotropica-induced pneumonia.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- The Likelihood of Misidentifying Rodent Pasteurellaceae by Using Results from a Single PCR Assay.Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- Article
- Exhaust Air Dust Monitoring is Superior to Soiled Bedding Sentinels for the Detection of Pasteurella pneumotropica in Individually Ventilated Cage Systems.Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
- Neonatal Pulmonary Macrophage Depletion Coupled to Defective Mucus Clearance Increases Susceptibility to Pneumonia and Alters Pulmonary Immune Responses.American journal of respiratory cell and molecular biology · 2016Article
- An Agent-Based Model of a Hepatic Inflammatory Response to Salmonella: A Computational Study under a Large Set of Experimental Data.PloS one · 2016Article
- Therapeutic and prevention strategies against human enterovirus 71 infection.World journal of virology · 2015Review
- Characterization of Biofilm Formation in [Pasteurella] pneumotropica and [Actinobacillus] muris Isolates of Mouse Origin.PloS one · 2015Article
- Overexpression of IL-10 in C2D macrophages promotes a macrophage phenotypic switch in adipose tissue environments.PloS one · 2014Article
- Protective role of Toll-like receptor 4 in experimental gonococcal infection of female mice.Mucosal immunology · 2012Article
- Molecular and virulence characteristics of an outer membrane-associated RTX exoprotein in Pasteurella pneumotropica.BMC microbiology · 2011Article
- Enhanced virulence of Chlamydia muridarum respiratory infections in the absence of TLR2 activation.PloS one · 2011Article
- Male CD81 knockout genotype disrupts Mendelian distribution of offspring.Comparative medicine · 2010Article
- Perturbations in cytokine gene expression after inoculation of C57BL/6 mice with Pasteurella pneumotropica.Comparative medicine · 2010Article
- Identification and characterization of hemolysin-like proteins similar to RTX toxin in Pasteurella pneumotropica.Journal of bacteriology · 2009Article
- Differentiation of C2D macrophage cells after adoptive transfer.Clinical and vaccine immunology : CVI · 2008Article
- Comparative toll-like receptor 4-mediated innate host defense to Bordetella infection.Infection and immunity · 2005Article
- Genetic diversity on 16S rDNA sequence and phylogenic tree analysis in Pasteurella pneumotropica strains isolated from laboratory animals.Current microbiology · 2005Article
- Toll-like receptor 4-dependent early elicited tumor necrosis factor alpha expression is critical for innate host defense against Bordetella bronchiseptica.Infection and immunity · 2004Article
- Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice.Infection and immunity · 2004Article
- Delayed clearance of Ehrlichia chaffeensis infection in CD4+ T-cell knockout mice.Infection and immunity · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
This study investigates Toll-like receptor 4 (TLR4)-positive macrophages in early recognition and clearance of pulmonary bacteria. TLR4 is a trans-membrane receptor that is the primary recognition molecule for lipopolysaccharide of gram-negative bacteria. The TLR4(Lps-del) mouse strains C57BL10/ScN (B10) and STOCK Abb(tm1) TLR4(Lps-del) Slc11a1(s)(B10 x C2D) are susceptible to pulmonary infections and develop pneumonia when naturally or experimentally infected by the opportunistic bacterium Pasteurella pneumotropica. Since these mice have the TLR4(Lps-del) genotype, we hypothesized that reconstitution of mice with TLR4-positive macrophages would provide resistance to this bacterium. A cultured macrophage cell line (C2D macrophages) and bone marrow cells from C2D mice were adoptively transferred to B10 and B10 x C2D mice by intraperitoneal injection. C2D macrophages increased B10 and B10 x C2D mouse resistance to P. pneumotropica. In C2D-recipient mice there was earlier transcription of tumor necrosis factor alpha and chemokines JE and macrophage inflammatory protein 2 (MIP-2) in the lungs of B10 and B10 x C2D mice, and there was earlier transcription of KC and MIP-1alpha in B10 x C2D mice. In addition, the course of inflammation following experimental Pasteurella challenge was altered in C2D recipients. C2D macrophages also protected B10 x C2D mice, which lack CD4(+) T cells. These data indicate that macrophages are critical for pulmonary immunity and can provide host resistance to P. pneumotropica. This study indicates that TLR4-positive macrophages are important for early recognition and clearance of pulmonary bacterial infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.