ArticleProceedings of the National Academy of Sciences of the United States of America2003
Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 116 citations in OpenAlex.
- Advances in Cutaneous Melanoma Therapy: The Emerging Role of CDK4/6 Inhibitors.Pharmacological research · 2025Review
- Review
- Higher Mutation Burden in High Proliferation Compartments of Heterogeneous Melanoma Tumors.International journal of molecular sciences · 2021Article
- Genetic and molecular biology of breast cancer among Iranian patients.Journal of translational medicine · 2019Review
- Targeting the cyclin dependent kinase and retinoblastoma axis overcomes standard of care resistance in BRAFOncotarget · 2018Article
- Mouse models of UV-induced melanoma: genetics, pathology, and clinical relevance.Laboratory investigation; a journal of technical methods and pathology · 2017Review
- Induction of Therapeutic Senescence in Vemurafenib-Resistant Melanoma by Extended Inhibition of CDK4/6.Cancer research · 2016Article
- Review
- The circadian clock controls sunburn apoptosis and erythema in mouse skin.The Journal of investigative dermatology · 2015Article
- Current State of Animal (Mouse) Modeling in Melanoma Research.Cancer growth and metastasis · 2015Review
- Novel UV-induced melanoma mouse model dependent on Endothelin3 signaling.Pigment cell & melanoma research · 2014Article
- Establishment and characterization of a primary and a metastatic melanoma cell line from Grey horses.In vitro cellular & developmental biology. Animal · 2014Article
- The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma.Molecular and cellular biology · 2013Article
- Loss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC.Cancer research · 2013Article
- Reconstructing skin cancers using animal models.Cancer metastasis reviews · 2013Review
- Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes.Cancer discovery · 2013Article
- Topical application of thymidine dinucleotide to newborn mice reduces and delays development of UV-induced melanomas.The Journal of investigative dermatology · 2012Article
- Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment.Nature communications · 2012Article
- Animal models of melanoma: a somatic cell gene delivery mouse model allows rapid evaluation of genes implicated in human melanoma.Chinese journal of cancer · 2011Review
- Somatic p16(INK4a) loss accelerates melanomagenesis.Oncogene · 2010Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies support a link between melanoma risk and UV exposure early in life, yet the molecular targets of UV's mutagenic actions are not known. By using well characterized murine models of melanoma, we provide genetic and molecular evidence that identifies components of the Rb pathway as the principal targets of UV mutagenesis in murine melanoma development. In a melanoma model driven by H-RAS activation and loss of p19(ARF) function, UV exposure resulted in a marked acceleration in melanoma genesis, with nearly half of these tumors harboring amplification of cyclin-dependent kinase (cdk) 6, whereas none of the melanomas arising in the absence of UV treatment possessed cdk6 amplification. Moreover, UV-induced melanomas showed a strict reciprocal relationship between cdk6 amplification and p16(INK4a) loss, which is consistent with the actions of UV along the Rb pathway. Most significantly, UV exposure had no impact on the kinetics of melanoma driven by H-RAS activation and p16(INK4a) deficiency. Together, these molecular and genetic data identify components of the Rb pathway as critical biological targets of UV-induced mutagenesis in the development of murine melanoma in vivo.
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