ArticleProceedings of the National Academy of Sciences of the United States of America2003
Sodium ion cycling mediates energy coupling between complex I and ATP synthase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The Cross-Species Implantable ATP Battery Inspired by Photosynthesis for Application in Diseases.International journal of nanomedicine · 2026Review
- Engineered mitochondria in diseases: mechanisms, strategies, and applications.Signal transduction and targeted therapy · 2025Review
- Towards Synthetic Cells with Self-Producing Energy.ChemPlusChem · 2024Review
- Novel complete methanogenic pathways in longitudinal genomic study of monogastric age-associated archaea.Animal microbiome · 2023Article
- Artificial organelles for sustainable chemical energy conversion and production in artificial cells: Artificial mitochondrion and chloroplasts.Biophysics reviews · 2023Review
- Energy-converting hydrogenases: the link between HCellular and molecular life sciences : CMLS · 2020Review
- The proton pumping bo oxidase from Vitreoscilla.Scientific reports · 2019Article
- The deactive form of respiratory complex I from mammalian mitochondria is a Na+/H+ antiporter.The Journal of biological chemistry · 2012Article
- Engineering rotor ring stoichiometries in the ATP synthase.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Biochemistry, evolution and physiological function of the Rnf complex, a novel ion-motive electron transport complex in prokaryotes.Cellular and molecular life sciences : CMLS · 2011Review
- Possible roles of two quinone molecules in direct and indirect proton pumps of bovine heart NADH-quinone oxidoreductase (complex I).Biochimica et biophysica acta · 2010Article
- Specific modification of a Na+ binding site in NADH:quinone oxidoreductase from Klebsiella pneumoniae with dicyclohexylcarbodiimide.Journal of bacteriology · 2006Article
- Characterization of a multigene-encoded sodium/hydrogen antiporter (sha) from Pseudomonas aeruginosa: its involvement in pathogenesis.Journal of bacteriology · 2005Article
- Genome-wide transcriptional profiling of the steady-state response of Pseudomonas aeruginosa to hydrogen peroxide.Journal of bacteriology · 2005Article
- The dichotomy of complex I: a sodium ion pump or a proton pump.Proceedings of the National Academy of Sciences of the United States of America · 2003Review
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We show here sodium ion cycling between complex I from Klebsiella pneumoniae and the F(1)F(0) ATP synthase from Ilyobacter tartaricus in a reconstituted proteoliposome system. In the course of NADH oxidation by complex I, an electrochemical sodium ion gradient was established and served as a driving force for the synthesis of ATP from ADP and phosphate. In the opposite direction, the deltamu(Na(+)) generated by ATP hydrolysis could be coupled to NADH formation by reversed electron transfer from ubiquinol to NAD. For reverse electron transfer, a transmembrane voltage larger than 30 mV was obligatory. No NADH-driven proton transport into the lumen of proteoliposomes was detected. We conclude that Na(+) is used as the exclusive coupling ion by the enterobacterial complex I.
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