ArticleProceedings of the National Academy of Sciences of the United States of America2003
Hair-bundle movements elicited by transepithelial electrical stimulation of hair cells in the sacculus of the bullfrog.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Electrical Control of the Transduction Channels' Gating Force in Mechanosensory Hair Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Efferent control of hair cells mechanically coupled by artificial membranes.Scientific reports · 2025Article
- Neural control and innate self-tuning of the hair cell's active process.Biophysical journal · 2024Article
- A universal description of stochastic oscillators.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Atypical tuning and amplification mechanisms in gecko auditory hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Effects of Efferent Activity on Hair Bundle Mechanics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Active Biomechanics of Sensory Hair Bundles.Cold Spring Harbor perspectives in medicine · 2019Review
- Article
- Frequency sensitivity in mammalian hearing from a fundamental nonlinear physics model of the inner ear.Scientific reports · 2017Article
- CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.Nature communications · 2017Article
- Chemomechanical regulation of myosin Ic cross-bridges: Deducing the elastic properties of an ensemble from single-molecule mechanisms.PLoS computational biology · 2017Article
- The Skull Vibration-Induced Nystagmus Test of Vestibular Function-A Review.Frontiers in neurology · 2017Review
- An elastic element in the protocadherin-15 tip link of the inner ear.Nature communications · 2016Article
- Reverse transduction measured in the living cochlea by low-coherence heterodyne interferometry.Nature communications · 2016Article
- Voltage-Mediated Control of Spontaneous Bundle Oscillations in Saccular Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Power dissipation in the subtectorial space of the mammalian cochlea is modulated by inner hair cell stereocilia.Biophysical journal · 2015Article
- Recovery of otoacoustic emissions after high-level noise exposure in the American bullfrog.The Journal of experimental biology · 2014Article
- Adaptation of mammalian auditory hair cell mechanotransduction is independent of calcium entry.Neuron · 2013Article
- A prestin motor in chicken auditory hair cells: active force generation in a nonmammalian species.Neuron · 2013Article
- Mechanical overstimulation of hair bundles: suppression and recovery of active motility.PloS one · 2013Article
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2 authors.
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Abstract
Electrically evoked otoacoustic emission is a manifestation of reverse transduction by the inner ear. We present evidence for a single-cell correlate of this phenomenon, hair-bundle movement driven by transepithelial electrical stimulation of the frog's sacculus. Responses could be observed at stimulus frequencies up to 1 kHz, an order of magnitude higher than the organ's natural range of sensitivity to acceleration or sound. Measurements at high-stimulus frequencies and pharmacological treatments allow us to distinguish two mechanisms that mediate the electrical responses: myosin-based adaptation and Ca(2+)-dependent reclosure of transduction channels. These mechanisms also participate in the active process that amplifies and tunes the mechanical responses of this receptor organ. Transient application of the channel blocker gentamicin demonstrated the crucial role of mechanoelectrical transduction channels in the rapid responses to electrical stimulation. A model for electrically driven bundle motion that incorporates the negative stiffness of the hair bundle as well as its two mechanisms of motility captures the essential features of the measured responses.
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