ArticleProceedings of the National Academy of Sciences of the United States of America2003
Discovery of the breast cancer gene BASE using a molecular approach to enrich for genes encoding membrane and secreted proteins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
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- Genomic Instability of Mutation-Derived Gene Prognostic Signatures for Hepatocellular Carcinoma.Frontiers in cell and developmental biology · 2021Article
- Insulinoma-associated protein 1 (INSM1): a potential biomarker and therapeutic target for neuroendocrine tumors.Cellular oncology (Dordrecht, Netherlands) · 2020Review
- A four-gene transcript score to predict metastatic-lethal progression in men treated for localized prostate cancer: Development and validation studies.The Prostate · 2019Article
- Peptidase inhibitor 15 as a novel blood diagnostic marker for cholangiocarcinoma.EBioMedicine · 2019Article
- Expression of sushi domain containing two reflects the malignant potential of gastric cancer.Cancer medicine · 2018Article
- Longitudinal autoantibody responses against tumor-associated antigens decrease in breast cancer patients according to treatment modality.BMC cancer · 2018Article
- Pleomorphic adenoma of salivary gland and synchronous/metachronous invasive ductal breast cancer: a casual coincidence or a clinical presentation resulting from common genetic events?International journal of clinical and experimental pathology · 2018Article
- SUSD2 promotes tumor-associated macrophage recruitment by increasing levels of MCP-1 in breast cancer.PloS one · 2017Article
- SUSD2 expression in high-grade serous ovarian cancer correlates with increased patient survival and defective mesothelial clearance.Oncogenesis · 2016Article
- Global transcriptome and sequenome analysis of formalin-fixed salivary epithelial-myoepithelial carcinoma specimens.Genes, chromosomes & cancer · 2015Article
- Classifying patients for breast cancer by detection of autoantibodies against a panel of conformation-carrying antigens.Cancer prevention research (Philadelphia, Pa.) · 2014Article
- Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.Caries research · 2014Article
- Multiple functions of sushi domain containing 2 (SUSD2) in breast tumorigenesis.Molecular cancer research : MCR · 2013Article
- CAPC negatively regulates NF-κB activation and suppresses tumor growth and metastasis.Oncogene · 2012Article
- Progranulin (GP88) tumor tissue expression is associated with increased risk of recurrence in breast cancer patients diagnosed with estrogen receptor positive invasive ductal carcinoma.Breast cancer research : BCR · 2012Article
- Structure, function, and mechanism of progranulin; the brain and beyond.Journal of molecular neuroscience : MN · 2011Review
- Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily.Biochemical Society transactions · 2011Article
- Mapping tissue-specific expression of extracellular proteins using systematic glycoproteomic analysis of different mouse tissues.Journal of proteome research · 2010Article
- Latherin: a surfactant protein of horse sweat and saliva.PloS one · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
To identify unknown membrane proteins that could be used as targets for breast and prostate cancer immunotherapies and secreted proteins to be used as diagnostic markers, a cDNA library was generated from membrane-associated polyribosomal RNA derived from four breast cancer cell lines, one normal breast cell line, and a prostate cancer cell line. The membrane-associated polyribosomal cDNA library was subtracted with RNA from normal brain, liver, lung, kidney, and muscle. Of the 15,581 clones sequenced from the subtracted cDNA library, sequences from 10,506 clones map to known genes, but 5,075 sequences, representing 3,181 unique transcripts, are not associated with known genes. As one example, we experimentally investigated expression of a previously uncharacterized breast cancer gene that encodes a secreted protein designated BASE (breast cancer and salivary gland expression). BASE is expressed in many breast cancers but not in essential normal tissues including the five organs used for subtraction. Further analysis of this library should yield additional gene products of use in the diagnosis or treatment of breast or prostate cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.